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IRCT20230926059521N1 IRCT 2023-11-14 Esfahan University of Medical Sciences Comparative evaluation of teraputic effects (improving indicators) related to Recurrent HerpesLabialis using Nano and mocoadhesive formulation of acyclovir and acyclovir_clobetasole Comparative evaluation of teraputic effects (improving indicators) related to Recurrent HerpesLabialis using Nano and mocoadhesive formulation of acyclovir and acyclovir_clobetasole 2017-08-23 anticipated 80 Complete https://irct.ir/trial/72878 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: The researcher and the patient were not aware of the type of medicine received from the beginning of the treatment until the end, and the pharmacist provided the medicine in the form of an ointment with labels that had the code a, b, c, or d, and only the pharmacist and the statistical analyzer of the type of medicine related to each Labels were known, the researcher gave the drugs to the study participants and the results related to each type of label were given to the statistical analyzer. 0 (exploratory trials) Recurrent herpes labialis. Intervention group: 80 patients with recurrent labial herpes. No - There is not a plan to make this available Justification or reason for not sharing IPD is Publication of individual data according to the researcher's opinion is not allowed
public solmazmohamadi
isfahan univercity of medical science
isfahan Iran (Islamic Republic of) 8861637641 038332225243 solmazmohamadi.dnt2@gmail.com Esfahan University of Medical Sciences scientific zahra golestannezhad
isfahan univercity of medical science
isfahan Iran (Islamic Republic of) 81745319 +98 31 3668 5149 Dr_zgolestan@yahoo.com Esfahan University of Medical Sciences Iran (Islamic Republic of) (The lesion is recurrent (secondary) and not primary in any case. 2) The age range of the patient should be between 18 and 60 years. does not. 5) The patient should not use any lip moisturizing topical cosmetics or sun cream in the lesion area during the treatment, and should not perform any manipulations such as scratching or facial modification in the area. 6) The lesion should be in the papule-vesicle stage 18 years 60 years Both Having an allergy to acyclovir or a history of severe allergy to other drugs. 2) Using topical or systemic drugs to treat recurrent herpes labialis in the last 4 weeks. 3) Suffering from systemic diseases or liver and kidney failure diseases. 4) Using Contraceptive pills and breastfeeding. 5) suffering from immunodeficiency and acquired diseases Treatment - Drugs Intervention group: 80 patients with recurrent labial herpes The amount of pain or burning was calculated and recorded by the patient with a score scale, and the time of dressing the scab and recovery time was recorded by the clinician. Timepoint: 1st to 7th day after delivery of medicine. Method of measurement: The amount of pain or burning was calculated and recorded by the patient with a score scale, and the time of dressing the scab and recovery time was recorded by the clinician. Isfahan University of Medical Sciences Approved 2017-08-23 Ethics committee of isfahan University of Medical Sciences isfahan University of Medical Sciences isfahan Isfehan Iran (Islamic Republic of)