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IRCT20230714058773N4 IRCT 2023-10-10 Armed forces institute of dentistry CMH Rawalpindi Comparison of celecoxib versus acetaminophen as pre-emptive analgesics for the management of post operative pain after impacted mandibular third molar surgery Comparison of celecoxib versus acetaminophen as pre-emptive analgesics for the management of post operative pain after impacted mandibular third molar surgery 2021-02-18 anticipated 75 Complete https://irct.ir/trial/72955 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive. 2 Condition 1: Third molar surgery. Condition 2: Pain. Condition 3: Celecoxeb. Intervention 1: Intervention group:35 patients received an oral dose of 200 mg of Celecoxeb 30 minutes before surgery. All operations were performed by the same surgeon and the efficacy of both drugs were evaluated by the same surgeon. Patients were educated properly on how to record their pain intensity on the visual analogue scale by placing a vertical mark across the horizontal line of the VAS at the point they felt the pain at 4, 6 and 8 hours after urgery. Each patient revisited for follow up with their records of pain at 4, 6 and 8 hours after surgery and total number of tablets consumed within 24 hours. Intervention 2: Control group:35 patients received an oral dose of 500 mg of acetaminophen 30 minutes before surgery. All operations were performed by the same surgeon and the efficacy of both drugs were evaluated by the same surgeon. Patients were educated properly on how to record their pain intensity on the visual analogue scale by placing a vertical mark across the horizontal line of the VAS at the point they felt the pain at 4, 6 and 8 hours after urgery. Each patient revisited for follow up with their records of pain at 4, 6 and 8 hours after surgery and total number of tablets consumed within 24 hours. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information

public Tehmina Maryam

Range road Rawalpindi

Rawalpindi Pakistan 46000 +92 333 9576737 Tehminamaryam27@gmail.com Armed forces institute of dentistry CMH Rawalpindi scientific Tehmina Maryam

Armed forces institute of dentistry CMH Rawalpindi

Rawalpindi Pakistan 46000 +92 333 9576737 Tehminamaryam27@gmail.com Armed forces institute of dentistry CMH Rawalpindi Pakistan Male and female aged from 17 to 50 years old Patients with at least one impacted mandibular third molar that is indicated for surgical extraction and also confirmed by periapical radiographs including mesioangular, distoangular, horizontal and vertical impactions Patients with no intake of analgesic and anti-inflammatory drugs for 1 week. 17 years 50 years Both Patients with conditions in which the use of NSAIDs and COX-2 inhibitors is contraindicated. Patients with serious diseases like liver, kidney and cardiovascular diseases Pregnant or nursing women Patients with ulcers or bleeding in the digestive tract. Patients who are unable to express subjective discomfort symptoms. Patients with periodontal disease involving the adjacent teeth K01.1 R52 Y45.3 Impacted teeth Pain, unspecified Other nonsteroidal anti-inflammatory drugs [NSAID] Treatment - Drugs Treatment - Drugs Intervention group:35 patients received an oral dose of 200 mg of Celecoxeb 30 minutes before surgery. All operations were performed by the same surgeon and the efficacy of both drugs were evaluated by the same surgeon. Patients were educated properly on how to record their pain intensity on the visual analogue scale by placing a vertical mark across the horizontal line of the VAS at the point they felt the pain at 4, 6 and 8 hours after urgery. Each patient revisited for follow up with their records of pain at 4, 6 and 8 hours after surgery and total number of tablets consumed within 24 hours. Control group:35 patients received an oral dose of 500 mg of acetaminophen 30 minutes before surgery. All operations were performed by the same surgeon and the efficacy of both drugs were evaluated by the same surgeon. Patients were educated properly on how to record their pain intensity on the visual analogue scale by placing a vertical mark across the horizontal line of the VAS at the point they felt the pain at 4, 6 and 8 hours after urgery. Each patient revisited for follow up with their records of pain at 4, 6 and 8 hours after surgery and total number of tablets consumed within 24 hours. Pain. Timepoint: 30 minutes before intervention and 4,6,8 hours after intervention. Method of measurement: The visual analogue scale comprised a horizontal line, 10cm in length with word descriptors at each endpoint, 0 at the left end presenting "no pain" and point 10 at the right end representing "worst possible pain.". Armed forces institute of dentistry CMH Rawalpindi Approved 2021-12-21 Ethics committee of armed forces institute of dentistry CMH Rawalpindi Range road Rawalpindi Rawalpindi Punjab Pakistan