IRCT20231009059661N1 IRCT 2023-12-30 Islamic Azad University Isfahan(Khorasgan) branch research Deputy Effect of aerobic exercise and supplement on ROS and neurogenesis in depressed postmenopausal women Effect of aerobic exercise and Aphrodite supplement on the level of some oxidative stress factors and neurogenesis of transmitters related to mental and psychological disorders of postmenopausal women with depression 2023-11-01 anticipated 200 Complete https://irct.ir/trial/73092 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Depression. Intervention 1: Intervention group 1: twelve weeks aerobic exercise, from 50 pre cent of HRm(in first week) to 70 pre cent of that in last five weeks. Intervention 2: Intervention group 2: 12 weeks of aerobic training plus Aphrodite supplement twice a day (each capsule contains 40 mg of sea buckthorn fruit, 72.12 mg of ginger, 3.3 mg of saffron and 11 mg of cinnamon and weighs approximately 70 mg has it . Intervention 3: Intervention group 3: using Aphrodite supplement twice a day for twelve weeks (each capsule contains 40 mg of sea buckthorn fruit, 72.12 mg of ginger, 3.3 mg of saffron and 11 mg of cinnamon and weighs approximately 70 mg has it ). Intervention 4: Control group: without intervention. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is after ending of study