IRCT20231013059708N1 IRCT 2023-11-25 Mashhad University of Medical Sciences The effect of Viola drop on dry eye Investigating the effect of Viola Odorata eye drop on dry eye disease: a randomized clinical trial 2024-01-01 anticipated 52 Complete https://irct.ir/trial/73155 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The randomization method in this design will be block method. Blocks of 4 will be used and the sequence produced by the website https://www.sealedenvelope.com will be provided by the project methodologist and will be placed in closed, sealed, opaque and numbered envelopes and the researcher assistant opens one of the envelopes and the patient will be allocated to the group mentioned in the envelope, Blinding description: The drug and placebo will be packed in the same cans, and only the code and method of administration will be written on them. The patient and specialist and the statistical analyst are unaware of the assigned codes, and at the end of the study, the code is decoded by an informed person. The participant, the researcher, the statistical analyst and Data Safety and Monitoring Committee are unaware of the arrangement of groups. 3 Dry Eye Syndrome. Intervention 1: Intervention group: Eye drops containing 15 cc of aqueous violet extract (two grams per hundred milliliters) for four weeks, one drop four times a day. Intervention 2: Control group: Eye drops containing 15 cc of placebo for six weeks, one drop four times a day. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information