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IRCT20190202042583N5 IRCT 2023-11-11 Mazandaran University of Medical Sciences Comparing the effect of acetaminophen and ibuprofen in reducing the pain of venipuncture Comparison of the effect of acetaminophen syrup with oral ibuprofen in reducing pain caused by peripheral vascularization in children with acute lymphoblastic leukemia. 2023-11-22 anticipated 30 Complete https://irct.ir/trial/73180 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Other, Purpose: Supportive, Randomization description: We divide each client into two groups using a random table. This table is a set of numbers. Consider the numbers 1 to 19 for intervention A and the numbers 20 to 38 for control B (for both size groups larger and smaller than 4 cm). Then we touch one of the numbers and move into one of the predetermined directions and record the numbers and assign them to one of the groups. In this way, patients are divided completely randomly, Blinding description: This Study is Double Blind and the patients and the care takers are unaware of the drugs type which have the same color, Volume and Tube.In addition, The psychiatrist observing the images is not aware of the type of medication received. 1-2 Acute lymphoblastic leukemia. Intervention 1: Intervention group: prescription of acetaminophen syrup with 15mg/kg dosing, once, taken orally 1hour before needle insertion. Intervention 2: Intervention group: prescription of Ibuprofen syrup with 1omg/kg dosing, once, taken orally 1hour before needle insertion. Intervention 3: Control group: prescription of placebo with same amount as previous drugs once, taken orally 1hour before needle insertion. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is the results will be published later
public Mohammad Naderisorki
Bu Ali Sina Hospital, Pasdaran Bulv
Sari Iran (Islamic Republic of) 4815838477 +98 11 3334 3011 Dr.naderisorki@gmail.com Mazandaran University of Medical Sciences scientific Mohammad Naderisorki
Bu Ali Sina Hospital, Pasdaran Bulv.
Sari Iran (Islamic Republic of) ۴۸۱۵۸۳۸۴۷۷ +98 11 3334 3011 Dr.naderisorki@gmail.com Mazandaran University of Medical Sciences Iran (Islamic Republic of) All Children between 3-12 years old diagnosed with ALL came for Chemotherapy 3 years 12 years Both People younger than 3 years old and older than 12 years old Neutrophil < 1500 Alergic history of Acetaminophen/ Ibuprofen Plt<50,000 Fever & Nausia/ Vomitting Hb < 8g/litre Hepatic disfunction C91.0 Acute lymphoblastic leukemia [ALL] Treatment - Drugs Treatment - Drugs Placebo Intervention group: prescription of acetaminophen syrup with 15mg/kg dosing, once, taken orally 1hour before needle insertion Intervention group: prescription of Ibuprofen syrup with 1omg/kg dosing, once, taken orally 1hour before needle insertion Control group: prescription of placebo with same amount as previous drugs once, taken orally 1hour before needle insertion Drug effects on pain reduction during IV needle insertion. Timepoint: Pain reduction of needle insertion 60 minutes after oral taking of drugs. Method of measurement: Ouches pain scale. Mazandaran University of Medical Sciences Approved 2023-08-15 Ethics committee of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, Se-rah-Joibar, Sari Sari Mazandaran Iran (Islamic Republic of)