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IRCT20220516054879N9 IRCT 2023-11-20 Rasht University of Medical Sciences Investigating the effect of Sildenafil topical cream compared to Dexpanthenol cream on neck wound healing The Evaluation of the Effect of Sildenafil Topical Cream with dexpanthenol on the Healing Process of Scar Caused by Neck Surgeries: A Double Blinded Randomized Controlled Trial 2023-11-22 anticipated 46 Complete https://irct.ir/trial/73287 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The 4 permutation block randomization method was used to randomize patients into two groups. Given that Group A is the intervention group and Group B is the control group. Randomization was done with SAS software version 9. For allocation concealment, opaque-sealed envelopes will be used, Blinding description: This study will be conducted in a double-blind manner, so that two topical creams containing sildenafil and dexpanthenol will be prepared for the treatment and control groups in the Faculty of Pharmacy and delivered to the therapist in similar containers with A and B labels. The type of treatments will be placed inside a sealed envelope delivered to the statistical analyst, and the therapist and the patient will not know the type of treatment. 3 Scar caused by neck surgery. Intervention 1: Intervention group: Receive Sildenafil 5% topical cream three times a day. Intervention 2: Control group: Receiving dexpanthenol 5% topical cream 3 times a day from Pharmachemy pharmaceutical company for three months. No - There is not a plan to make this available Justification or reason for not sharing IPD is Preservation of patients' privacy and compliance with ethical principles
public Maryam Shahrokhi
17shahrivar Hospital, Shahid Siadati Street, Namjoo Street
Rasht Central African Republic 414465379 +98 13 3336 9019 shahrokhi.mail85@gmail.com Rasht University of Medical Sciences scientific Maryam Shahrokhi
17shahrivar Hospital, Shahid Siadati Street, Namjoo Street
Rasht Iran (Islamic Republic of) 4144654379 +98 13 3336 9019 shahrokhi.mail85@gmail.com Rasht University of Medical Sciences Iran (Islamic Republic of) -Patients over 18 years of age who have neck wounds caused by surgery and refer to Amir al-Momenin Hospital in Rasht.- No previous allergy to products containing sildenafil- Not using other drugs that are effective in wound healing- Absence of diseases that interfere with wound healing (chronic systemic diseases of the heart, kidneys, lungs, coagulation disorder, immune deficiency, connective tissue disorder, diabetes, anemia, hemophilia, and malnutrition)- No history of injury or previous surgery and visible lesions in the neck area 18 years no limit Both L90.5 Scar conditions and fibrosis of skin Treatment - Drugs Placebo Intervention group: Receive Sildenafil 5% topical cream three times a day. Control group: Receiving dexpanthenol 5% topical cream 3 times a day from Pharmachemy pharmaceutical company for three months Scar spread. Timepoint: Scar spread will be measured at the beginning of the study and then weekly for 3 months. Method of measurement: Based on the observation of the researcher. Erythema. Timepoint: Erythema will be measured at the beginning of the study and then weekly for 3 months. Method of measurement: Based on the observation of the researcher. Rasht University of Medical Sciences Approved 2023-10-18 Ethics committee of Guilan University of Medical Sciences Deputy of research and technology, In front of 17 shahrivar hospital, Shaid siadati street,Namjoo street, Rasht Rasht Guilan Iran (Islamic Republic of)