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IRCT20231031059914N1 IRCT 2023-11-13 Mashhad University of Medical Sciences Effect of Coffee on Eye The Effect of Caffeine on Choroidal Thickness, Vascularization index, and Anterior Segment Parameters of the Eye in healthy population 2023-12-06 anticipated 50 Complete https://irct.ir/trial/73472 interventional Randomization: N/A, Blinding: Single blinded, Placebo: Used, Assignment: Crossover, Purpose: Treatment, Blinding description: In this study, the participants will be unaware of the presence or absence of caffeine in each phase of the study. N/A Condition 1: Choroidal thickness changes. Condition 2: Changes in anterior segment factors. Condition 3: Changes in choroidal vascular index. Intervention 1: Intervention group: These people are given caffeinated coffee. Intervention 2: Control group: These people are given decaffeinated coffee. Yes - There is a plan to make this available What will be shared: The non-identified information of people will be accessible to people after the publication of the article. When: The access period starts 3 months after the publication of the article To whom: The public will be allowed to access the information. Conditions: For all scientific requests, documents can be used. Where to obtain: Contact the following Email: I.Varshovi@Gmail.com How to obtain: The request will be sent to the individual within one month after being raised in the clinical trial scientific group. Comments:
public Iman Varshovi-Jaghargh
Unit 8, No. 13, Hashemieh 63
Mashhad Iran (Islamic Republic of) 9178175751 +98 51 3881 8761 I.Varshovi@gmail.com Mashhad University of Medical Sciences scientific Asieh Ehsaei
Unit 7, No. 23, Mina 6, Mina Ave., Bahar 18, Sajjad Blvd.
Mashhad Iran (Islamic Republic of) 9174324401 +98 51 3884 6719 Ehsaeia@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Ocular health in normal examination Not using hard contact lenses in the last month Not using soft contact lenses in the last two weeks Personal consent to participate in the research project Not consuming coffee at least 4 hours before attending the program No smoking Not drinking coffee or any caffeinated drinks during the test 20 years 50 years Both History of systemic and ophthalmic disease People with cardiac arrhythmia History of hypertension, diabetes, glaucoma, uveitis Pregnancy and breastfeeding Taking medications that affect posterior and anterior segment of the eye History of eye surgery N/A N/A Intervention group: These people are given caffeinated coffee. Control group: These people are given decaffeinated coffee. Choroidal vascularity index. Timepoint: Before intervention and 1, 2, 3, and 4 hours after intervention. Method of measurement: Posterior and anterior optical coherence tomography. Angle-opening distance. Timepoint: Before intervention and 1, 2, 3, and 4 hours after intervention. Method of measurement: Posterior and anterior optical coherence tomography. Trabecular iris angle. Timepoint: Before intervention and 1, 2, 3, and 4 hours after intervention. Method of measurement: Posterior and anterior optical coherence tomography. Trabecular iris space area. Timepoint: Before intervention and 1, 2, 3, and 4 hours after intervention. Method of measurement: Posterior and anterior optical coherence tomography. Anterior chamber depth. Timepoint: Before intervention and 1, 2, 3, and 4 hours after intervention. Method of measurement: Posterior and anterior optical coherence tomography. Choroidal thickness. Timepoint: Before intervention and 1, 2, 3, and 4 hours after intervention. Method of measurement: Posterior and anterior optical coherence tomography. Corneal thickness. Timepoint: Before intervention and 1, 2, 3, and 4 hours after intervention. Method of measurement: Posterior and anterior optical coherence tomography. Choroidal luminal thickness. Timepoint: Before intervention and 1, 2, 3, and 4 hours after intervention. Method of measurement: Posterior and anterior optical coherence tomography. Choroidal stromal thickness. Timepoint: Before intervention and 1, 2, 3, and 4 hours after intervention. Method of measurement: Posterior and anterior optical coherence tomography. Mashhad University of Medical Sciences Approved 2023-10-07 Research Ethics Committees of Mashhad University of Medical Sciences Qureishi Building, Daneshgah Street, Mashhad Mashhad Razavi Khorasan Iran (Islamic Republic of)