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IRCT20120215009014N489 IRCT 2023-11-09 Hamedan University of Medical Sciences Effect of topical solution hydrogen peroxide 40% versus cryotherapy on the treatment of seborrheic keratosis lesions Effect of topical solution hydrogen peroxide 40% versus cryotherapy on the treatment of seborrheic keratosis lesions: a single-blind randomized clinical trial 2023-11-22 anticipated 30 Complete https://irct.ir/trial/73488 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, random assignment of the right and left sides of the patients to the intervention and control groups will be carried out using the drawing of lots. To achieve this, two sheets will be prepared, one with "right" written on it and the other with "left." For each patient, one sheet will be randomly taken from the container. Based on whether the given sheet is labeled as "right" or "left," it will be assigned to the intervention group or the opposite side will be allocated to the control group, Blinding description: The randomization process will be conducted by a separate individual from the one who examines the patients, ensuring that the examining person remains unaware of the intervention. Therefore, the trial will be conducted as a single-blind study. 3 Seborrheic keratosis. Intervention 1: Intervention group: In the hydrogen peroxide treatment method, a 40% hydrogen peroxide solution is placed on the seborrheic keratosis lesions with a cotton swab for 20 seconds and repeated after 60 seconds. This treatment is repeated once a week for 6 weeks. Intervention 2: Control group: In the cryotherapy treatment method, a cotton swab dipped in liquid nitrogen is placed on the seborrheic keratosis lesions with a margin of 1 to 2 mm from the surrounding healthy skin until it is frozen and after complete melting, this operation is repeated again. This treatment is repeated every two weeks for 6 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It depends on the situation and the results of the study as well as the approval of the financial supporting organization.
public Dr Forough Bouryabaf
School of Medicine, Hamadan University of Medical Sciences, Fahmideh Ave.
Hamadan Iran (Islamic Republic of) 6517838695 +98 81 3838 0572 foroughbouryabaf@gmail.com Hamedan University of Medical Sciences scientific Dr. Bahareh Ebrahimi
School of Medicine, Hamadan University of Medical Sciences, Fahmideh Ave.
Hamadan Iran (Islamic Republic of) 6517838695 +98 81 3838 0572 b.ebrahimi.4362@googlel.com Hamedan University of Medical Sciences Iran (Islamic Republic of) Age 18 to 70 years Bilateral facial seborrheic keratosis 18 years 70 years Both Pregnancy or breastfeeding History of using anti-pigmentation drugs in the last 3 months Presence of wound, infection or active skin disease at the treatment site Lesions on the eyelids or around the eyes L82 Seborrheic keratosis Treatment - Drugs Treatment - Drugs Intervention group: In the hydrogen peroxide treatment method, a 40% hydrogen peroxide solution is placed on the seborrheic keratosis lesions with a cotton swab for 20 seconds and repeated after 60 seconds. This treatment is repeated once a week for 6 weeks. Control group: In the cryotherapy treatment method, a cotton swab dipped in liquid nitrogen is placed on the seborrheic keratosis lesions with a margin of 1 to 2 mm from the surrounding healthy skin until it is frozen and after complete melting, this operation is repeated again. This treatment is repeated every two weeks for 6 weeks. Improvement rate of keratosis seborrheic lesions. Timepoint: In 2, 4, and 6 weeks after treatment. Method of measurement: By clinical examination. Pain and burning. Timepoint: 20 minutes after treatment. Method of measurement: By taking history. Erythema. Timepoint: 20 minutes after treatment. Method of measurement: With clinical examination. Edema. Timepoint: 20 minutes after treatment. Method of measurement: With clinical examination. Hypopigmentation. Timepoint: 20 minutes after treatment. Method of measurement: With clinical examination. Hyperpigmentation. Timepoint: 20 minutes after treatment. Method of measurement: With clinical examination. Hamedan University of Medical Sciences Approved 2023-10-28 Ethics Committee of Hamadan University of Medical Sciences Vice-chancellor for Research and Technology, Hamadan University of Medical Sciences, Fahmideh Ave Hamadan Hamadan Iran (Islamic Republic of)