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IRCT20231104059949N1 IRCT 2023-12-14 Zabol University of Medical Sciences Comparison of the effect of endotracheal suction using two methods, endotracheal N-acetylcysteine and normal saline, on hemodynamic parameters and arterial blood gases in intubated patients under mechanical Comparison of the effect of endotracheal suction using two methods, endotracheal N-acetylcysteine and normal saline, on hemodynamic parameters and arterial blood gases in intubated patients under mechanical 2023-12-11 anticipated 90 Complete https://irct.ir/trial/73520 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Factorial, Purpose: Supportive, Randomization description: By simple randomization method using lottery First, three study groups are randomly assigned. Then, the code is written to the total number of the sample volume, and to allocate the samples for groups 1, 2, 3, each specified code is allocated by lottery, Blinding description: In this study, the patients are not aware of the treatment group due to the decreased level of consciousness and are kept blind. After the patient meets the conditions for entering the study, informed consent is obtained from the first-degree family members of the patient, but they do not know about the type of intervention that has been performed. 3 Patients should be intubated and under mechanical ventilation.. Intervention 1: Intervention group: Endotracheal suction with N-acetylcysteine is such that 2 ml of 20% N-acetyl cysteine liquid solution is poured by the researcher into the patient's tracheal tube during suction and it is suctioned immediately. Intervention 2: Intervention group: Endotracheal suction with normal saline is done in such a way that 3 ml of sterile normal saline serum is poured by the researcher into the patient's tracheal tube during suctioning and it is suctioned immediately. Intervention 3: Control group: Endotracheal suction without inoculating solution. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information.
public Ahmad Absalan
No. 14, Farokhi Sistani St. 2, Basij Blvd., Zabul City
Zabul Iran (Islamic Republic of) 9861866494 +98 54 3223 0469 ahmadabsalan0@gmail.com Zabol University of Medical Sciences scientific Ahmad Absalan
No. 14, Farokhi Sistani St. 2, Basij Blvd., Zabul City
Zabul Iran (Islamic Republic of) 9861866494 +98 54 3223 0469 ahmadabsalan0@gmail.com Zabol University of Medical Sciences Iran (Islamic Republic of) Patients who are connected to mechanical ventilation for at least 48 hours and at most one week Patients with endotracheal tubes Patients who are between 20 and 60 years old Patients who are hemodynamically stable (heart rate between 60-100 beats per minute, blood pressure between 160/100-110/60 mmHg, Spo2 more than 90%, urinary output more than 30 ml/hour) Patients with normal electrolyte levels and no cardiac arrhythmia Insensitivity to N-acetylcysteine and other drugs Absence of pulmonary edema, chronic obstructive pulmonary diseases and asthma Patients who do not have chest trauma or chest tube Absence of brain edema, spinal cord injury, increased intracranial pressure 20 years 60 years Both Patients who are hemodynamically unstable (heart rate less than 60 beats per minute, blood pressure less than 100/60 mmHg, Spo2 less than 90%) Any changes in mechanical ventilation settings during the study Death of the patient Lack of consent of the patient's family Use of muscle relaxants and inotropic drugs during the study Z99.11 Dependence on respirator [ventilator] status Rehabilitation Rehabilitation Rehabilitation Intervention group: Endotracheal suction with N-acetylcysteine is such that 2 ml of 20% N-acetyl cysteine liquid solution is poured by the researcher into the patient's tracheal tube during suction and it is suctioned immediately. Intervention group: Endotracheal suction with normal saline is done in such a way that 3 ml of sterile normal saline serum is poured by the researcher into the patient's tracheal tube during suctioning and it is suctioned immediately. Control group: Endotracheal suction without inoculating solution Heart rate, which is considered as a hemodynamic parameter. Timepoint: The heart rate is measured at the beginning of the study (before the intervention) and 1, 5 and 30 minutes after the intervention. Method of measurement: It is controlled and recorded by means of monitoring connected to the patient. Blood pressure, which is considered as a hemodynamic parameter. Timepoint: The blood pressure is measured at the beginning of the study (before the intervention) and 1, 5 and 30 minutes after the intervention. Method of measurement: It is controlled and recorded by means of monitoring connected to the patient. Arterial oxygen saturation, which is considered as a hemodynamic parameter. Timepoint: The Arterial oxygen saturation is measured at the beginning of the study (before the intervention) and 1, 5 and 30 minutes after the intervention. Method of measurement: It is controlled and recorded by means of monitoring connected to the patient. Respiratory rate, which is considered as a hemodynamic parameter. Timepoint: The Respiratory rate is measured at the beginning of the study (before the intervention) and 1, 5 and 30 minutes after the intervention. Method of measurement: For 1 minute, the Respiratory rate is counted and recorded in the patient's chest by observation method. Arterial blood gases include PH, PCO2, PO2, HCO3, SPO2. Timepoint: Arterial blood gases are measured at the beginning of the study (5 minutes before the intervention) and 25 minutes after the intervention. Method of measurement: Blood gas Technomedica Arterial Blood Gas Analyzer Gastat-720 series. Zabol University of Medical Sciences Approved 2023-10-11 Ethics committee of Zabul University of Medical Sciences University of Medical Sciences, Rajaei St., Zabul City Zabul Sistan-va-Balouchestan Iran (Islamic Republic of)