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IRCT20130812014333N211 IRCT 2023-11-25 Kermanshah University of Medical Sciences Comparison of the effects of clonidine and tranexamic acid on the rate of bleeding during nose surgery Comparative study of the effects of clonidine and tranexamic acid on the rate of bleeding during rhinoplasty surgery. Clinical trial 2023-12-06 anticipated 92 Complete https://irct.ir/trial/73808 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization will be done in a simple random method, after identifying eligible patients, they will be randomly assigned a three-digit dedicated code. The last digit on the right determines the patient group. If this number is 0, 1, 2, 3, 4, it will be assigned in the first intervention group, and if this number is 5, 6, 7, 8, 9, it will be assigned in the second intervention group, Blinding description: In this double-blind study, the patients are aware of their participation in the study and receiving the medication, but the outcome evaluator is blinded to the allocation of the study groups and the medication they received. N/A Rhinoplasty. Intervention 1: The first intervention group will receive 700 micrograms of tranexamic acid per kilogram of body weight orally two hours before surgery. Intervention 2: The second intervention group will receive 2 micrograms of clonidine per kilogram orally 90 minutes before surgery. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Maryam safdari
Emam Reza Hospital, Parastar Boulevard
kermanshah Iran (Islamic Republic of) 6715847141 +98 83 3427 6306 sainasfd@gmail.com Kermanshah University of Medical Sciences scientific Dr. Mohammad Bagher Heydari
Emam Reza Hospital, Parastar Boulevard
Kermanshah Iran (Islamic Republic of) 6715847141 +98 83 3427 6306 sainasfd@gmail.com Kermanshah University of Medical Sciences Iran (Islamic Republic of) Informed consent Age between 18-60 years 18 years 50 years Both Addiction to narcotics and benzodiazepines History of seizures Suffering from liver and kidney failure, diabetes, lung and heart diseases, coagulation disorders History of allergy to clonidine and tranexamic acid drugs pregnancy M95.0 Acquired deformity of nose Treatment - Drugs Treatment - Drugs The first intervention group will receive 700 micrograms of tranexamic acid per kilogram of body weight orally two hours before surgery The second intervention group will receive 2 micrograms of clonidine per kilogram orally 90 minutes before surgery. Bleeding rate. Timepoint: The beginning of the study and the end of the study. Method of measurement: Based on the amount of blood collected in the suction. Kermanshah University of Medical Sciences Approved 2023-09-03 Ethics committee of Kermanshah University of Medical Sciences Vice Chancellor for Research Affairs, Kermanshah University of Medical Sciences, Building No.2, Shahid Beheshti Boulevard Kermanshah Kermanshah Iran (Islamic Republic of)