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IRCT201107046942N1 IRCT 2011-07-21 National Research Institute of Tuberculosis & Lung Disease The effect of interpleural and intravenous morphine on pain after video-assisted thoracoscopic surgery Comparison of interpleural versus intravenous morphine for pain relief after video-assisted thoracoscopic Surgery 2010-10-23 anticipated 40 Complete https://irct.ir/trial/7398 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Other, Purpose: Treatment. 4 Two different analgesic methods after VATS. Intervention 1: At the end of VATS, eligible patients in control group will receive a single bolus of 0.1 mg/kg of morphine intravenously. Intervention 2: At the end of VATS, eligible patients in intervention group will receive a single bolus of 0.1 mg/kg of morphine interpleurally.
public Dr. Tahereh Parsa
Tracheal Disease Research Center, Masih Daneshvari Hospital, Darabad, Niavaran,
Tehran Iran (Islamic Republic of) 1956944413 +98 21 2610 9644 tparsa849@yahoo.com National Research Institute of Tuberculosis & Lung Disease scientific Dr. Shideh Dabir
Department of Anesthesiology, Masih Daneshvari Hospital, Darabad, Niavaran,
Tehran Iran (Islamic Republic of) 1956944413 +98 21 2610 9644 info@nritld.ac.ir Tracheal Diseases Research Center, National Research Institute of Tuberculosis & Lung Disease Iran (Islamic Republic of) Inclusion criteria: ASA Class 1& 2, Age more than or equal 18, Weight more than or equal 40 kg, no limitations in terms of sex, height, surgery duration, type of surgical procedure, number and location of chest tubes. Exclusion criteria: Opium/alcohol addiction, drug abuse, mental retardation, psychological disorders, severe pleural adhesions and fibrosis, bronchopleural fistula, severe empyema, ASA class more than or equal 3, opioid consumption prior to surgery, inability to clamp chest tubes after surgery 18 years 70 years Both Y90, Y91, Supplementary factors related to causes of morbidity and mortality classified elsewhere Treatment - Drugs Treatment - Drugs At the end of VATS, eligible patients in control group will receive a single bolus of 0.1 mg/kg of morphine intravenously At the end of VATS, eligible patients in intervention group will receive a single bolus of 0.1 mg/kg of morphine interpleurally Pain severity after VATS. Timepoint: every one hour during the first postoperative 8 hours. Method of measurement: Visual analoge scale, supplemental analgesic consumption. Mean arterial pressure. Timepoint: every one hour during first postoperatve 8 hours. Method of measurement: NIBP. Heart rate. Timepoint: every one hour during first postoperatve 8 hours. Method of measurement: ECG. SPO2. Timepoint: every one hour during first postoperatve 8 hours. Method of measurement: pulse oxymeter. Side effects (nausea, vomiting,pruritus, respiratory depression). Timepoint: every one hour during first postoperatve 8 hours. Method of measurement: observation and question. Sedation score. Timepoint: every one hour during first postoperatve 8 hours. Method of measurement: Ramsay sedation scale. National Research Institute of Tuberculosis & Lung Disease Approved 2004-11-20 National Research Institute of Tuberculosis & Lung Disease Masih Daneshvari Hospital, Darabad, Niavaran Tehran Iran (Islamic Republic of)