IRCT201112146948N2 IRCT 2011-12-26 Isfahan University of Medical Sciences Treatment of acetaminophen toxicity Comparison of the adverse effects of intravenous N-acetylcysteine with intravenous and oral N-acetylcystein in acetaminophen toxicity 2009-03-21 anticipated 50 Complete https://irct.ir/trial/7404 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A acetaminphen toxicity. Intervention 1: The group A (only intravenous N-acetylcystein or NAC) was managed by IV NAC with 150mg/kg infused in 200cc of 5% dextrose water (5%DW) in 30 minutes, followed by a 4 hour infusion of 50mg/kg of NAC in 500cc of 5%DW and finally with a 16 hour infusion of 100mg/kg NAC in 1000cc 5%DW. Intervention 2: In group B (oral and IV NAC), oral NAC was given by 140mg/kg in 200cc of 5%DW. If vomiting occurred in any patient during one hour after the ingestion of the oral NAC then 10mg metoclopramide was given IM and the oral NAC was given with the same dose again. If there was no vomiting again then the administration of NAC was continued by IV route by 50mg/kg in 500cc of 5%DW in four hour infusion and then 100mg/kg in 1000cc of 5%DW in 16 hour infusion.