]>
IRCT20231129060219N1 IRCT 2024-07-20 Mashhad University of Medical Sciences Investigating the effect of Fasd on acne Investigating the effect of Persian medicine Fasd on symptoms of patients with acne vulgaris 2024-06-24 anticipated 60 Complete https://irct.ir/trial/74077 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Factorial, Purpose: Treatment, Randomization description: At first, the participants in the study are divided into two groups, male and female. Then six blocks of 4 will be created and a number will be assigned to each of the blocks: AABB(1)- ABAB(2)-ABBA(3)-BBAA(4)- BABA (5) - BAAB (6). Using the table of random numbers, a list will be selected from numbers 1 to 6 and randomization of the participants of both groups will be done based on the prepared list. 3 Acne Vulgaris. Intervention 1: Control group: Benzoyl Peroxide Gel 5% twice a day topically plus Doxycycline 100 mg capsule twice a day orally Plus Cephalic vein phelebotomy in the elbow crease area with an 18 Gauge Needle and drawing 150-200 cc blood at the beginning of the study and end of second month. Intervention 2: Control group: Benzoyl Peroxide Gel 5% twice a day topically plus Doxycycline 100 mg capsule twice a day orally. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It is not yet known if there will be a plan to make this available
public Mostafa Khosravi Moghaddam
School of Persian And Complementary Medicine, University campus, Azadi Square
Mashhad Iran (Islamic Republic of) 9177899191 +98 51 3884 8931 Khosravimm5@mums.ac.ir Mashhad University of Medical Sciences scientific Alireza Derakhshan
School of Persian and Complementary Medicine, University campus, Azadi square
Mashhad Iran (Islamic Republic of) 9177948564 +98 51 3884 8931 Derakhshanar@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) People aged 16 to 25 years Moderate to severe acne based on GAGS criteria Not having general cold Mizaj (temperament) based on diagnosis of traditional Persian medicine expert and valid Mizaj questionnaire Willingness to cooperate in the project 16 years 25 years Both Having other skin diseases other than acne Having serious liver and kidney diseases Patients with iron deficiency anemia Use of topical acne medicine in the last 2 weeks or any systemic anti-acne antibiotic treatment in the last 1 month or isotretinoin in the last 6 months Use of acne-causing drugs in the last month Chemical or laser peeling or UV treatment or photosensitizing drugs in the last month Drug sensitivity to tetracycline derivatives or benzoyl peroxide General cold temperament based on validated Mezaj questionnaire Body Mass Index lower than 19 Breastfeeding Pregnancy Patients diagnosed with Polycystic ovary syndrome Mentally retarded patients L70.0 Acne vulgaris Treatment - Other Treatment - Drugs Control group: Benzoyl Peroxide Gel 5% twice a day topically plus Doxycycline 100 mg capsule twice a day orally Plus Cephalic vein phelebotomy in the elbow crease area with an 18 Gauge Needle and drawing 150-200 cc blood at the beginning of the study and end of second month Control group: Benzoyl Peroxide Gel 5% twice a day topically plus Doxycycline 100 mg capsule twice a day orally Acne severity according to Global Acne Grading Score Index. Timepoint: At beginning of study and end of every month till 3 month. Method of measurement: Global Acne Grading Score Index. Quality of Life according Cardiff Disability Index. Timepoint: At beggining of Study and end of 3th month. Method of measurement: According Cardiff Acne Disability Index. Mashhad University of Medical Sciences Approved 2024-02-24 Ethics committee of Mashhad University of Medical Sciences Medical schoolŲŒ Mashhad University of Medical Sciences, Azadi Square Mashhad Razavi Khorasan Iran (Islamic Republic of)