IRCT201111266959N3 IRCT 2012-01-11 Skin research center of Shahid Beheshti university of medical sciences The evaluation of efficacy of topical use of Nigella cream (Nigella sativa oil-extract) in chonic hand eczema The evaluation of efficacy of topical use of Nigella cream (Nigella sativa oil-extract) in comparison with topical use of 0.1% Betamethasone and Eucerin on the clinical severity and quality of life in patients with chonic hand eczema reffering to Loghman-e-Hakim and Shohada-e-Tajrish hospitals during the year 1388-1389 2010-01-01 anticipated 60 Complete https://irct.ir/trial/7417 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 3 hand eczema. Intervention 1: The nigella cream with eucerin base is made by a valid pharmacology company. For blinding the participants but not investigators, all three creams( Nigella, Betamethasone, eucerin as placebo) will be prepared in the identical tubes which only labeled A, B, and C with no other information. Intervention group Participants will apply maximally one gram of study drugs topically on eczematous lesions twice a day for a period of four weeks; the amount of applied creams is estimated by Finger Tip Unit (FTU). Intervention 2: We use Eucerin as a creamy base for the nigella oil so we use eucerin as a placebo. The Eucerin cream will be prepared in tubes with the same weight and appearance to nigella cream tubes and randomly will be administered for the patients. In this group the eucerin cream is applied twice daily for 4 weeks in amount of a finger tip units and the maximum dose is 1 gr per each application. Intervention 3: We use Eucerin as a creamy base for the nigella oil so we use eucerin as a base for betamethasone cream too. The betamethasone cream will be prepared in tubes with the same weight and appearance to nigella and placebo cream tubes and randomly will be administered for the patients. In this group the betamethasone cream is applied twice daily for 4 weeks in amount of a finger tip units and the maximum dose is 1 gr per each application.