IRCT20180209038673N7 IRCT 2024-01-02 Yazd University of Medical Sciences The effects of bolus infusion versus continuous injection of doxorubicin in children with ALL The comparison of bolus infusion versus continuous injection of doxorubicin in children with ALL 2023-12-20 anticipated 60 Complete https://irct.ir/trial/74204 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The randomization of the the two intervention groups is done based on quadruple blocks in Excel software. In this software, the intervention groups (A, and B) are placed alternately. In the next column, there are quadruple blocks. At the end, the random digits created by the software RND0 function are placed. We then arrange the numbers based on block columns and random values, Blinding description: In this study, the researcher does not know about prescription drugs. This means that the researcher knows the two groups only as group A and group B and has no knowledge of which intervention group the patients have been placed in. In other words, the researcher does not know which intervention groups A and B have received. 3 Acute lymphoblastic leukemia. Intervention 1: Intervention group: Group A patients receive adriamycin through bolus injection. Before the intervention and 6 months after the intervention, the patients undergo echocardiography. The dose of Adriamycin is 40-60 mg/m2 and it is purchased from Türkiye. Intervention 2: Intervention group: Group B patients receive adriamycin through continuous infusion. Before the intervention and 6 months after the intervention, the patients undergo echocardiography. The dose of Adriamycin is 40-60 mg/m2 and it is purchased from Türkiye. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information