IRCT20231206060281N1 IRCT 2023-12-14 Gorgan University of Medical Sciences : The effect of curcumin supplementation as adjunctive therapy in the treatment of patients with bipolardisorder-Depression : The effect of curcumin supplementation as adjunctive therapy in the treatment of patients with bipolardisorder-Depression 2023-12-16 anticipated 72 Complete https://irct.ir/trial/74259 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, people will be divided into two groups by random block method. First, we will check the initial score of the BDRS questionnaire of the people and put all 4 people with almost the same questionnaire score in one block. Then we will choose a block from the following blocks by a simple random method with replacement and based on the permutation of letters in that block, the patients will receive the treatments. 1. ABBA 2. AABB 3. BAAB 4. BABA 5. BBAA 6. ABAB, Blinding description: This study will be conducted in a single-blind manner, and the neuropsychological assistants will not be involved in the type of treatment the patients will receive. Each patient's treatment type will be delivered inside identical envelopes to conceal random allocation and prevent guessing. To maintain blinding, drugs will be delivered to patients by another research team member (other than the neuropsychiatric assistant). 3 Bipolar disorder. Intervention 1: Intervention group: In addition to the previous usual drugs (sodium valproate and risperidone or olanzapine or ketamine), they will receive 2 tablets of curcumin 500 mg daily for 6 weeks. Intervention 2: Control group: They will continue the same drug treatment as before for 6 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is After collecting the data, we will hold a meeting with the research team and decide on how to publish the data.