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IRCT20231217060434N1 IRCT 2024-01-26 Faculty of Physical Education and Sport Sciences - University of Tehran The effects of exercise and supplement on infertile women with PCOS The effect of high-intensity interval training and nanocurcumin consumption of microRNAs(miRNA) 29a-5P, 93 and Anti Mullerian Hormone(AMH) in infertile women with polycystic ovary syndrome 2024-02-20 anticipated 40 Complete https://irct.ir/trial/74485 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Factorial, Purpose: Basic scienece, Randomization description: Forty beads are placed in a box numbered from 1 to 4. After accepting each patient and obtaining informed consent, one of the beads is randomly took out of the box, and people are classified into different groups based on the number on the beads, so that numbers 1 belong to the group of HIIT, numbers 2: nanoCurcumin supplement, Numbers 3: HIIT+nanocurcumin, numbers 4: placebo. In general, this will be done on 40 patients, Blinding description: The method of blinding will be in a way that the patients will be unaware of their treatment group, and the training-supplement group will receive nanocurcumin and the training-placebo group will receive capsules containing flour. 3 Condition 1: Polycystic ovary syndrome. Condition 2: Female infertility. Intervention 1: Intervention group 1: exercise-supplement. Subjects of the exercise-supplement group take one 80 mg capsule of nanocurcumin with a daily dose during the period. High-intensity interval training starts with 80% HRmax and ends with 95% HRmax in the last weeks. These exercises are held 3 days a week and each training session lasts for 30 minutes (5 minutes of warming up, 15 minutes of training, 10 minutes of cooling down) and includes 4 hours. Each set consists of 4 movements, each of which is performed for 30 seconds with high intensity and takes 15 seconds. Intervention 2: Intervention group2: Exercise-placebo group. They receive capsules containing flour. Because the exercise + supplement group and the exercise group will both exercise together in the hall, the exercise group will also be given a placebo so that the two groups of patients do not notice the difference between people. High-intensity interval training starts with 80% HRmax and ends with 95% HRmax in the last weeks. These exercises are held 3 days a week and each training session lasts for 30 minutes (5 minutes of warming up, 15 minutes of training, 10 minutes of cooling down) and includes 4 hours. Each set consists of 4 movements, each of which is performed for 30 seconds with high intensity and takes 15 seconds. Intervention 3: Intervention group 3: supplementary group. Subjects in the supplement group will take 80 mg nanocurcumin capsules at a daily dose during the period. Intervention 4: Control group: Also, the control group will use a placebo (containing flour, but if not used, the people in the control group will be prone to celiac disease). No - There is not a plan to make this available Justification or reason for not sharing IPD is Due to participants' demands and the condition of this matter to participate in the project and to protect their privacy, the data will be preserved, but in case of reasonable request from the relevant organizations or people, the information of the project will be available
public Amir hossain Delshad
After Quds settlement, Al-Ghadir Boulevard, Qom
Qom Iran (Islamic Republic of) 3716146611 +98 25 3210 3693 ah_delshad@yahoo.com The University of Qom scientific Mohammad reza kordi
Faculty of Physical Education and Sport Sciences, between 15th and 16th street, North Kargar street, Tehran
Tehran Iran (Islamic Republic of) 37 - 88351730 +98 21 8802 1527 mrkordi@ut.ac.ir The University of Tehran Iran (Islamic Republic of) Infertile women Women with PCOS Age between 20 and 38 years (fertility age) 20 years 38 years Female Cardiovascular disease Respiratory disease Using hormonal drugs E28.2 N97 Polycystic ovarian syndrome Female infertility Other Other Treatment - Drugs Placebo Intervention group 1: exercise-supplement. Subjects of the exercise-supplement group take one 80 mg capsule of nanocurcumin with a daily dose during the period. High-intensity interval training starts with 80% HRmax and ends with 95% HRmax in the last weeks. These exercises are held 3 days a week and each training session lasts for 30 minutes (5 minutes of warming up, 15 minutes of training, 10 minutes of cooling down) and includes 4 hours. Each set consists of 4 movements, each of which is performed for 30 seconds with high intensity and takes 15 seconds. Intervention group2: Exercise-placebo group. They receive capsules containing flour. Because the exercise + supplement group and the exercise group will both exercise together in the hall, the exercise group will also be given a placebo so that the two groups of patients do not notice the difference between people. High-intensity interval training starts with 80% HRmax and ends with 95% HRmax in the last weeks. These exercises are held 3 days a week and each training session lasts for 30 minutes (5 minutes of warming up, 15 minutes of training, 10 minutes of cooling down) and includes 4 hours. Each set consists of 4 movements, each of which is performed for 30 seconds with high intensity and takes 15 seconds. Intervention group 3: supplementary group. Subjects in the supplement group will take 80 mg nanocurcumin capsules at a daily dose during the period. Control group: Also, the control group will use a placebo (containing flour, but if not used, the people in the control group will be prone to celiac disease). MicroRNA 29a-5P. Timepoint: before the start of the intervention and 3 months after the intervention at the end of the work. Method of measurement: blood test. Anti Mullerian Hormone. Timepoint: before the start of the intervention and 3 months after the intervention at the end of the work. Method of measurement: blood test. MicroRNA 93. Timepoint: before the start of the intervention and 3 months after the intervention at the end of the work. Method of measurement: blood test. Body Mass Index. Timepoint: before the start of the intervention and 3 months after the intervention at the end of the work. Method of measurement: BMI formula. Iranian academic center for education culture and research Faculty of Physical Education and Sport Sciences - University of Tehran Rouya Infertility Center Approved 2023-11-26 Faculty of Physical Education and Sport Sciences - University of Tehran Faculty of Physical Education and Sport Sciences, between 15th and 16th street, North Kargar street, Tehran Tehran Tehran Iran (Islamic Republic of)