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IRCT20231222060494N1 IRCT 2024-01-07 Ardabil University of Medical Sciences Effects of etomidate, propofol and etomidate combined with propofol on hemodynamic changes in high blood pressure patients Investigating the effects of etomidate, propofol and etomidate combined with propofol injections on hemodynamic changes in high blood pressure patients who are candidates for general anesthesia 2024-02-20 anticipated 150 Complete https://irct.ir/trial/74685 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be randomly divided into three groups receiving propofol, etomidate and etomidate and propofol. Randomization in this study is done by simple randomization method using RAND function of Excel software. First, 150 random numbers are created in one column using the Rand function. Then, in the second column of the numbers from 1 to 150, a new random code is inserted in front of each column. Finally, in the third column, 50 lines with code A, 50 lines with code B, and 50 lines with code C are filled. After arranging the size of the numbers in the first column using the software, keeping their connection to the numbers in the second and third columns, the random sequence in the third column is ready. The numbers in the second column, each assigned to one of the three groups based on the corresponding line in the third column, can be used as the row code used in hiding, Blinding description: In patients of the intervention groups, the form of drugs will be the same. Patients and doctors who evaluate the outcome will be unaware of the type of drug received. 3 Hemodynamic status. Intervention 1: Intervention group: The group receiving propofol 1.5-2 mg/kg (Tehran shimi Co). Intervention 2: Intervention group: The group receiving etomidate 0 3 mg/kg (Aboreihan Co). Intervention 3: Intervention group: The group receiving etomidate and propofol (propofol 1 mg/kg and etomidate 0.15 mg/kg). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is The results are not yet known
public Somayye Najafpour
Fatemi hospital, Imam Khomeini street, Ardabil
Ardabil Iran (Islamic Republic of) 5614733775 +98 45 3323 2520 drsomayye@gmail.com Ardabil University of Medical Sciences scientific Somayye Najafpour
Fatemi hospital, Imam Khomeini street, Ardabil
Ardabil Iran (Islamic Republic of) 5614733775 +98 45 3323 2520 drsomayye@gmail.com Ardabil University of Medical Sciences Iran (Islamic Republic of) Patients with blood pressure between 140/80 and 170/90 are candidates for abdominal surgery 18 years no limit Both Patients with hemodynamic disorder who need therapeutic fluid and vasopressor. R03.0 Elevated blood-pressure reading, without diagnosis of hypertension Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group: The group receiving propofol 1.5-2 mg/kg (Tehran shimi Co) Intervention group: The group receiving etomidate 0 3 mg/kg (Aboreihan Co) Intervention group: The group receiving etomidate and propofol (propofol 1 mg/kg and etomidate 0.15 mg/kg) Blood pressure. Timepoint: The first, fifth and tenth minutes after induction. Method of measurement: Vital signs monitoring device. Pulse rate. Timepoint: The first, fifth and tenth minutes after induction. Method of measurement: Vital signs monitoring device. Ardabil University of Medical Sciences Approved 2023-12-04 Ethics committee of Shiraz University of Medical Sciences Ardabil University of Medical Sciences, Daneshgah Ave, Ardabil Ardabil Ardabil Iran (Islamic Republic of)