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IRCT20160306026938N19 IRCT 2024-02-19 Tehran University of Medical Sciences Comparing the effectiveness of the combination of caffeine, L-theanine and piperin compared to placebo and pure caffeine in increasing attention Investigating the effectiveness of capsules containing the combination of caffeine, L-theanine and piperin compared to pure caffeine and placebo in improving attention in healthy people 2024-02-14 anticipated 31 Complete https://irct.ir/trial/74697 interventional Randomization: N/A, Blinding: Double blinded, Placebo: Used, Assignment: Crossover, Purpose: Supportive, Blinding description: Participants: They all receive capsules of the same shape, same color, and same smell in all three experiments, and they cannot identify the difference in any way. Researcher: All the capsules are coded (in the envelope) and the researcher will not know about the nature of the codes of the medicine delivered to the subject and will only hand over the codes to subject to receive the medicine based on thje code from the second researcher. 2-3 Attention and concentration deficit. Intervention 1: Intervention group: will receive 1- Caffeine capsule containing 200 milligrams of pure caffeine, 2- placebo (containing 300 mg starch) and 3- Caffeine + theanine + piperine capsule, containing 150 ml of caffeine, 200 mg of theanine and 10 mg of piperine, respectively, without knowing the nature of medicine or placebo, orally with an interval of one week for each capsule. Intervention 2: Intervention group: will receive 1- placebo (containing 300 mg starch), 2- Caffeine capsule containing 200 milligrams of pure caffeine, and 3- Caffeine + theanine + piperine capsule, containing 150 ml of caffeine, 200 mg of theanine and 10 mg of piperine, respectively, without knowing the nature of medicine or placebo, orally with an interval of one week for each capsule. Intervention 3: Intervention group: will receive 1- Caffeine + theanine + piperine capsule, containing 150 ml of caffeine, 200 mg of theanine and 10 mg of piperine 2- Caffeine capsule containing 200 milligrams of pure caffeine, and 3- placebo (containing 300 mg starch), respectively, without knowing the nature of medicine or placebo, orally with an interval of one week for each capsule. Yes - There is a plan to make this available What will be shared: All data can be shared after de-identification. When: Access starts from 2026 To whom: Researchers working in academic and scientific institutions Conditions: Any type of analysis on the data is allowed, but they cannot use it as a document for making a supplement or medicine, or to prepare an article, solely based on the results of this study. Where to obtain: Dr. Mehdi Vazirian. Address: Advanced Research Laboratory of Pharmacognosy, Second Floor, New Building, Faculty of Pharmacy, Tehran University, Enqebal St., Tehran, Iran. Contact number: 02166959101, E. mail: mehdivazirian@gmail.com. How to obtain: Sending the official university application to Dr. Mehdi Vazirian's email, checking the authenticity and authenticity of the submitted application and sending the documents to the applicant's email. Comments:
public Mahdi Vazirian
Pharmacognosy Lab., Second Floor, New buliding, Faculty of Pharmacy, In front of Oruji Alley, 16th Azar Ave., Enqelab Ave.
Tehran Iran (Islamic Republic of) 1417614411 +98 21 6412 1223 Vazirian_m@tums.ac.ir Tehran University of Medical Sciences scientific Mahdi Vazirian
Pharmacognosy Lab., Second Floor, New buliding, Faculty of Pharmacy, In front of Oruji Alley, 16th Azar Ave., Enqelab Ave.
Tehran Iran (Islamic Republic of) 1417614411 +98 21 6412 1223 Vazirian_m@tums.ac.ir Tehran University of Medical Sciences Iran (Islamic Republic of) Regular consumption of tea or coffee (at least five cups per week) Regular consumption of breakfast Normal or corrected-to-normal vision Body mass index between 20 and 30 19 years 45 years Both Pregnancy or breastfeeding Having acute diseases (infectious or non-infectious) Suffering from incurable chronic diseases such as cancer or types of epilepsy Deficiency of immune system Smoking R41.840 Attention and concentration deficit Behavior Behavior Behavior Intervention group: will receive 1- Caffeine capsule containing 200 milligrams of pure caffeine, 2- placebo (containing 300 mg starch) and 3- Caffeine + theanine + piperine capsule, containing 150 ml of caffeine, 200 mg of theanine and 10 mg of piperine, respectively, without knowing the nature of medicine or placebo, orally with an interval of one week for each capsule. Intervention group: will receive 1- placebo (containing 300 mg starch), 2- Caffeine capsule containing 200 milligrams of pure caffeine, and 3- Caffeine + theanine + piperine capsule, containing 150 ml of caffeine, 200 mg of theanine and 10 mg of piperine, respectively, without knowing the nature of medicine or placebo, orally with an interval of one week for each capsule. Intervention group: will receive 1- Caffeine + theanine + piperine capsule, containing 150 ml of caffeine, 200 mg of theanine and 10 mg of piperine 2- Caffeine capsule containing 200 milligrams of pure caffeine, and 3- placebo (containing 300 mg starch), respectively, without knowing the nature of medicine or placebo, orally with an interval of one week for each capsule. Total attention score. Timepoint: Measuring attention at the beginning of the study (before the start of the intervention) and half an hour after taking the drug or placebo. Method of measurement: Integrated Visual and Auditory Continuous Performance Test. Tehran University of Medical Sciences Approved 2023-12-19 Tehran University of Medical Siences Tehran University of Medical Sciences, Qods street corner, Keshavarz Blvd, Tehran, Iran. Tehran Tehran Iran (Islamic Republic of)