IRCT20160523028008N30 IRCT 2024-01-17 Hamedan University of Medical Sciences The Determining the effect of vaginal probiotics on perinatal outcomes The Determining the effect of vaginal probiotics on perinatal outcomes in women with premature rupture of membranes 2024-01-20 anticipated 106 Complete https://irct.ir/trial/74803 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block randomization will randomly assign the cases to intervention and control groups. For this purpose, we will prepare four sheets of paper, writing on two sheets the name of the intervention and on the other two sheets the name of the control. The paper sheets will be pooled, placed in a container, and randomly drawn one at a time for each patient without replacement until all four sheets are removed. The four paper sheets will be then placed back into the container, and this action will be repeated until the sample size is reached, Blinding description: The person who examines patients for outcomes is not informed of the allocation of patients to the intervention and control groups. 2-3 Preterm spontaneous labour with term delivery. Intervention 1: Intervention group: Women with premature rupture of membranes are prescribed intravenous ampicillin 2 grams every 6 hours and then 500 milligrams of amoxicillin capsules every 8 hours for 5 days, as well as one gram of oral azithromycin tablets. In addition, vaginal probiotics from the Lactovazh brand by Biostakmir Company containing Lactobacillus rhamnosus (CU 109+Inulin) are given for two week. Intervention 2: Control group: Women with premature rupture of membranes are prescribed intravenous ampicillin 2 grams every 6 hours and then 500 milligrams of amoxicillin capsules every 8 hours for 5 days, as well as one gram of oral azithromycin tablets. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is not a plan to make this available