IRCT20240105060622N1 IRCT 2024-08-16 Tehran University of Medical Sciences comparing the effect of probiotics in cystic fibrosis comparing the effect of probiotics in improving pulmonary gastrointestinal symptoms with cystic fibrosis 2024-02-20 anticipated 108 Complete https://irct.ir/trial/74849 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Among the patients visiting the Cystic Fibrosis Clinic of the Children's Medical Center, 108 patients between the ages of 6 and 12 will be randomized into two groups: probiotic (case) and placebo (control).Blocking was done individually and in blocks of 10 in the form of 5 cases and 5 controls, And in order to hide the direction of the block, they will be allocated to two groups of cases and controls using the https://www.sealedenvelope.com/ system with a ratio of 1:1, Blinding description: Each Roteflor sachet contains 800 million active lyophilized cells of Lactobacillus roteri. Placebo is also made by Frabiotic similar to the main drug and provided to the researcher. 2-3 Cystic Fibrosis. Intervention 1: Intervention group: Patients in the probiotic group will receive Lactobacillus reuteri (Rotflor) at the rate of 10*8 CFU/d for one month. Intervention 2: Control group: Patients receive a placebo. Yes - There is a plan to make this available What will be shared: Data can potentially be shared after de-identifying individuals When: The access period starts 6 months after the results are published To whom: The data will be available to researchers working in academic and scientific institutions and people working in industry Conditions: Unlimited Where to obtain: dr mehri ayati.09126148071.dr.m.ayati61@gmail.com How to obtain: First, a clear request should be given by official email, the reason for the data request should be stated and the work to be done to the end. Comments: