]>
IRCT20220130053873N2 IRCT 2024-01-28 Tehran University of Medical Sciences Effectiveness of accelerated repetitive transcranial magnetic stimulation (rTMS) in resistant depression Evaluation of effectiveness of accelerated repetitive transcranial magnetic stimulation (rTMS) in adolescent patients resistant to one course of medication with antidepressants 2024-02-20 anticipated 15 Complete https://irct.ir/trial/75141 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A Major Depressive Disorder. Intervention group: The treatment sessions (TMS intervention) of the patient will be implemented during 3 weeks, which includes 6 treatment sessions. In the first week, the patient visits the unit three times, in the second week twice, and in the third week once. He receives treatment three times a day. rTMS protocol: rTMS intervention in the form of 120% of the movement threshold, with a frequency of 10 Hz for 2. 4 seconds and a rest interval of 15 seconds. Treatment sessions last for three 30-minute sessions with a 15-minute interval between sessions. The patient receives 10,500 pulses in each daily visit. (63000 pulses in total during the sessions). The motor cortex is determined by moving the active coil on the left hemisphere until finding the place that leads to the contraction of the left thumb muscle (abductor pollicis longus) and on the cap of The patient is marked. Threshold of active movement is the minimum intensity that leads to the contraction of the contracted muscle in at least half of ten times when performing magnetic movement. Then, the standard location of magnetic therapy stimulation - that is, the right dorsolateral prefrontal cortex - is determined by advancing the coil 5 cm from the point of the motor cortex towards the front.. Yes - There is a plan to make this available What will be shared: All data can be shared after de-identification When: The data can be made available 6 months after the results are published To whom: Researchers in academic and scientific institutions can access the data Conditions: Data can be used for systematic reviews and meta-analyses if needed. It is necessary to mention the names of the main researchers of this research. Where to obtain: In case of data request, write to jalaghbandrad@gmail.com. How to obtain: After receiving the request and its review by the main researcher, the data will be sent to the applicant along with a letter of commitment stating that the data will not be published without the name of the main researcher within one month. Comments:
public Javad Alaghband-rad
Roozbeh hospital. South kargar
Tehran Iran (Islamic Republic of) 1337159140 009855419151 jalaghbandrad@gmail.com Tehran University of Medical Sciences scientific Javad Alaghband-rad
Roozbeh hospital. South kargar
Tehran Iran (Islamic Republic of) 1337159140 009855419151 jalaghbandrad@gmail.com Tehran University of Medical Sciences Iran (Islamic Republic of) No treatment response to one trial of efficient dose with efficient durationModerate and severe depression defined by Hamilton score under 17 Informed Consent Right- handedness Age above 13 and under 18 13 years 18 years Both Suffering from major psychiatric disorders except simple phobia and nicotine dependency History of seizure in person or family Taking medications that lowers seizure threshold Risk of Suicide attempts Psychosis any magnetic or metal agent in he head or cardiac pacemaker Pregnancy No prior response to ECT F32 Major Depressive Disorder Treatment - Devices Intervention group: The treatment sessions (TMS intervention) of the patient will be implemented during 3 weeks, which includes 6 treatment sessions. In the first week, the patient visits the unit three times, in the second week twice, and in the third week once. He receives treatment three times a day. rTMS protocol: rTMS intervention in the form of 120% of the movement threshold, with a frequency of 10 Hz for 2. 4 seconds and a rest interval of 15 seconds. Treatment sessions last for three 30-minute sessions with a 15-minute interval between sessions. The patient receives 10,500 pulses in each daily visit. (63000 pulses in total during the sessions). The motor cortex is determined by moving the active coil on the left hemisphere until finding the place that leads to the contraction of the left thumb muscle (abductor pollicis longus) and on the cap of The patient is marked. Threshold of active movement is the minimum intensity that leads to the contraction of the contracted muscle in at least half of ten times when performing magnetic movement. Then, the standard location of magnetic therapy stimulation - that is, the right dorsolateral prefrontal cortex - is determined by advancing the coil 5 cm from the point of the motor cortex towards the front. Score of Hamilton depression rating scale. Timepoint: Prior to the study and 3 weeks later. Method of measurement: Hamilton Depression Rating Scale. Clinical Global Improvement. Timepoint: Prior to the study and 3 weeks later. Method of measurement: Clinical Global Impression questoinnaire. Tehran University of Medical Sciences Approved 2024-01-03 Ethics Committee of Tehran University of Medical Sciences Keshavarz Blvd Tehran Tehran Iran (Islamic Republic of)