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IRCT20220420054592N2 IRCT 2024-02-18 Yazd University of Medical Sciences Comparing the effect of mouthwash containing curcumin and oral nanocurcumin on gingivitis in patients with chronic gingivitis Comparing the effect of mouthwash containing curcumin and oral nanocurcumin on gingivitis in patients with chronic gingivitis who referred to Dental School of Shahid Sadoughi 2024-02-26 anticipated 30 Complete https://irct.ir/trial/75298 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization using Random allocation software. 2 Gingivitis. Intervention 1: Intervention group: The curcumin mouthwash group, For two weeks, 20 drops of 0.06% curcumin mouthwash in 10 ml water and rinse for 30 seconds 3 times a day. Intervention 2: Intervention group: Oral Nano-Curcumin, 80 mg Curcumin Nanomicelle Capsule (Sina Curcumin, prepared by ExirNanoSina, Tehran, Iran), Once a day after breakfast. Intervention 3: Intervention group: Chlorhexidine mouthwash, at home, use it twice a day for 1 minute according to the recipe and do not drink and eat for 30 minutes after mouth washing. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no more data.
public Arezoo Khabazian
Dental School, Imam Reza Blvd., End of Imam Reza St., Yazd, Iran
Yazd Iran (Islamic Republic of) 8914815667 +98 35 3625 5881 arezookhabazian@yahoo.com Yazd University of Medical Sciences scientific Arezoo Khabazian
Dental School, Imam Reza Blvd., End of Imam Reza St., Yazd, Iran
Yazd Iran (Islamic Republic of) 8914815667 +98 35 3625 5881 arezookhabazian@yahoo.com Yazd University of Medical Sciences Iran (Islamic Republic of) Patients with chronic gingivitis referred to the periodontics department of dental school No systemic disease (no history of gallstones or gallstone obstruction, no active gastrointestinal diseases, liver disease or immunosuppressive system) Age group 25 to 65 years old By matching age and gender in each group Insensitivity to turmeric and its compounds based on patient's self-declaration Needless to antibiotic prophylaxis Non-smoking Not using anti-inflammatory drugs for six weeks prior to and at the time of the check-up Lack of attachment loss Lack of periodontal treatment in the past six months Lack of pregnancy or breastfeeding No simultaneous anticoagulant and antiplatelet use 25 years 65 years Both Lack of patient cooperation Having symptoms of curcumin allergy K05 Gingivitis and periodontal diseases Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group: The curcumin mouthwash group, For two weeks, 20 drops of 0.06% curcumin mouthwash in 10 ml water and rinse for 30 seconds 3 times a day. Intervention group: Oral Nano-Curcumin, 80 mg Curcumin Nanomicelle Capsule (Sina Curcumin, prepared by ExirNanoSina, Tehran, Iran), Once a day after breakfast. Intervention group: Chlorhexidine mouthwash, at home, use it twice a day for 1 minute according to the recipe and do not drink and eat for 30 minutes after mouth washing. Gingival Index. Timepoint: In the first session and two weeks after the start of using oral rinses or nanocurcumin capsules depending on the patient group. Method of measurement: A probe and principles of the gingival index system identified by Leo. Plaque Index. Timepoint: In the first session and two weeks after the start of using oral rinses or nanocurcumin capsules depending on the patient group. Method of measurement: Plaque Index (silness-loe). Papillary Bleeding Index. Timepoint: In the first session and two weeks after the start of using oral rinses or nanocurcumin capsules depending on the patient group. Method of measurement: A probe and record bleeding points around each tooth. Yazd University of Medical Sciences Approved 2023-12-24 Ethics Committee of Shahid Sadoughi University of Medical Sciences Dental School, Imam Reza Blvd., End of Imam Reza St., Yazd, Iran Yazd Yazd Iran (Islamic Republic of)