IRCT20240207060924N1 IRCT 2024-02-17 Arak University of Medical Sciences Effect of Propofol in coronary bypass surgery Comparison of outcomes between Propofol and Dexmedetomidine on extubation time and vital signs in patients with post- coronary artery bypass grafting in Open heart Intensive Care Unit 2024-02-20 anticipated 92 Complete https://irct.ir/trial/75364 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, we will randomly divide 92 patients into two equal groups (P) and (D) using random block method. The randomization unit will be done individually and we will use statistical software as a tool. All statistical combinations that these two groups can have will be written. These combinations will include PPDD, PDDP, PDPD, DDPP, DPDP, DPPD. Now, using these combinations, the observations are placed into two intervention groups. Note that the intervention groups are chosen blindly, Blinding description: The aforementioned study is a double-blind study in which patients who meet the inclusion criteria and provide informed consent are assigned to one of two groups receiving Propofol (P) or Dexmedetomidine (D). Patients are randomized into groups (P) and (D) by the anesthesiologist and are unaware of which group they are in. In addition, the intern in charge of the project does not know the names of the groups. After the patients wake up and become conscious and are extubated while the sedative infusion is stopped, the student in charge of the project will be present in the ward to fill in the questionnaires, so he will not know about the studied groups and will be blinded. 3 Comparison of Outcomes Between Propofol and Dexmedetomidine in Post-Coronary Artery Bypass Graft Patients. Intervention 1: First intervention group: (P) that we infuse 10 cc per hour (10 cc/hr) for 4 to 6 hours from a vial of propofol 10% (manufactured by B. Braun, Germany). Intervention 2: Second intervention group: (D) In the Dexmedetomidine group, the syringe pump is filled to a volume of 50 cc and Dexmedetomidine is infused at a dose of 20 µ/hour (manufactured by Elixir Lorestan, Iran) for 4 to 6 hours. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I have not decided yet