IRCT20230731058990N4 IRCT 2024-03-18 University of Lahore, Lahore Neurodynamic and active release technique effects in carpal tunnel syndrome Therapeutic effects of neurodynamic and active release technique in carpal tunnel syndrome 2024-01-04 anticipated 18 Complete https://irct.ir/trial/76022 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Carpal tunnel syndrome, symptom severity index, disabilities of arm, shoulder and hand questionnaire, Phalen's test, Randomization description: Participants were randomized by using concealed envelope method. In this, sealed opaque envelops with treatment regimen written were provided to the participants. Once a patient had consented to enter a trial room, an envelope was opened, and the patient was then offered the allocated treatment, Blinding description: Assessor will only assess the patient at baseline,4th week and at 8th week for treatment outcomes. Assessor safe the data for follow-up and will not share it with any therapist or patient. At any stage, the assessor is unaware of the treatment and control group. The study was single-blinded. The assessor was unaware of the treatment given to either groups 1 or 2. 3 Carpal tunnel syndrome. Intervention 1: Intervention group: Group A received routine physical therapy included infrared. Infrared will be used for 10 minutes in each session. Total duration for each session with intervention will be 25-30 minutes. After baseline treatment, special techniques used for median nerve mobilization include gliding and tension maneuvers with duration of 5 minutes (8 repetitions in which we apply manual technique for 20s and rest for 10s) in each session. 1.Stand with your elbow resting at your side with the hand and fingers pulled back as far as pain allows. Keeping the hand and fingers pulled back gently straighten your elbow. 2. While standing, move the arm slightly out to the side and bring your wrist and hand backwards so your palm is facing outwards. Intervention 2: Intervention group: Group B received routine physical therapy included infrared. Infrared will be used for 10 minutes in each session. Total duration for each session with intervention will be 25-30 minutes. After baseline treatment, active release technique will be used which is a manual soft-tissue mobilization therapy, means that we use our hands to identify muscle adhesions. Patient will be in sitting position and we will approach to patient on his/her affected side and apply gentle pressure on adhesion point and move thumb on patient Flexor retinaculum clockwise and anticlockwise direction for 5 minutes. Yes - There is a plan to make this available What will be shared: Demographic data and data related to final outcome will be shared by maintaining the confidentiality. When: Data will be available from August 2024 to November 2024 after the 6 months of publication. The data sharing plan for a clinical trial (i.e., what data will be shared when and under what conditions) will be publicly available at a third-party site that shares data with and meets the data requirements of WHO's International Clinical Trials Registry Platform; this occur before the first participant is enrolled. To whom: Deidentified IPD and any additional information will be shared for the people working in academic institution and clinical research writers. Conditions: for research purpose Where to obtain: To the corresponding author of the study, Dr Sania Naz and can contact on +923044407035 saaniaanaz@gmail.com can visit these search engines, you can find my study easily here https://www.researchgate.net/ https://scholar.google.com/ How to obtain: Open-access and there is the traditional public data release where anyone can get access to the data with no registration or conditions. The request will be reviewed by Director in Charge and in case of eligibility, it would be shared in two weeks. Comments: I want randomized clinical trial registration.