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IRCT20190525043700N6 IRCT 2024-05-29 Babol University of Medical Sciences Comparing the Effectiveness of Memantine and Donepezil on elderly with dementia Comparing the Effectiveness of Memantine and Donepezil on the Cognitive Status of the elderly with vascular dementia 2024-06-21 anticipated 60 Complete https://irct.ir/trial/76695 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Allocation of patients in both groups of 30 memantine and donepezil is done by random block allocation method and free website www.randomization.com or http://randomizer.org is used to generate the allocation sequence. The obtained sequence is written on separate sheets and placed in sealed envelopes and given to the second colleague to conduct the study, Blinding description: The first colleague (student) is unaware of the random allocation list and which group each patient is in, and will be informed of the results at the end of the study. 3 Vascular dementia. Intervention 1: Patients in the memantine group are treated with memantine tablets 5 mg twice a day for one to two weeks, then 10 mg twice a day for up to 6 months. (From Actover pharmaceutical company). Intervention 2: Patients in the donepezil group are treated with 5 mg donepezil tablets daily for four to six weeks, then 10 mg daily for up to 6 months. No - There is not a plan to make this available Justification or reason for not sharing IPD is Maintain confidentiality
public Dr.Romina hamzehpour
Babol, Modares Street, Shahid Mostafa Khomeini Street, Yahainejad Hospital
Babol Iran (Islamic Republic of) 4713566547 +98 11 3222 3594 R.hamzehpour@mubabol.ac.ir Babol University of Medical Sciences scientific Dr.Romina hamzehpour
Farhang Crossroads, Yahainejad Hospital
Babol Iran (Islamic Republic of) 4713566547 +98 11 3222 3594 R.hamzehpour@mubabol.ac.ir Babol University of Medical Sciences Iran (Islamic Republic of) Age > 65 y MMSE Score < 24 + Evidence of metabolic disease Evidence in favor of vascular dementia in MRI 65 years no limit Both Patients with psychotic disorders Intellectual disability Patients who are already being treated for cognitive disorders Confirmed history of bipolar disorder or depression Patients with Alzheimer's and other neurological diseases F01.5 Vascular dementia Treatment - Drugs Treatment - Drugs Patients in the memantine group are treated with memantine tablets 5 mg twice a day for one to two weeks, then 10 mg twice a day for up to 6 months. (From Actover pharmaceutical company)... Patients in the donepezil group are treated with 5 mg donepezil tablets daily for four to six weeks, then 10 mg daily for up to 6 months.. Investigating the cognitive status by comparing the MMSE and Edenbrook test results at the beginning, during the treatment and at the end of the treatment. Timepoint: At the beginning of work, 3 months and 6 months after the start of treatment. Method of measurement: Through the Eden Brook test. Babol University of Medical Sciences Approved 2024-03-16 Health Research Institute - Babol University of Medical Sciences Babol, Murad Bey, University Square, Nurse St Babol Mazandaran Iran (Islamic Republic of)