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IRCT20240601061976N1 IRCT 2024-06-05 Ahvaz University of Medical Sciences Investigating the effect of memantine for the treatment of obsessions in bipolar patients The effect of memantine with a dose of 20 mg for the treatment of obsessions in bipolar patients with a fixed regimen of quetiapine and lithium 2024-06-21 anticipated 46 Complete https://irct.ir/trial/77155 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients with eligibility criteria will be divided into two groups using a randomized block design. An online website (https://www.sealedenvelope.com) generates a random list based on the desired sample size and block size of 4. After creating a list, each patient will be identified with a unique code throughout the study. 23 patients are selected for the intervention group and 23 for the control group, Blinding description: The participant, the researcher, and the treatment staff are kept blind, and the drugs are adjusted by a nurse not related to the research. 1-2 Bipolar. Intervention 1: Intervention group: In addition to routine bipolar treatment, 10 mg (Shafa Company) Memantine tablets as one tablet after a detailed history and confirmation of the patient's obsession. Intervention 2: Control group: In addition to the routine bipolar treatment, placebo tablets, which are similar to memantine tablets in terms of shape, smell, taste, size, and color, and are prepared by the Faculty of Pharmacy of Ahvaz University, are received in the same way as the intervention group. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Hamzeh Rostami
Golestan St., Esfand St., Ahvaz Jundishapur University of Medical Sciences
Ahvaz Iran (Islamic Republic of) 6441945781 +98 61 3311 0000 Rostami_h@ajums.ac.ir Ahvaz University of Medical Sciences scientific Hamzeh Rostami
Golestan St., Esfand St., Ahvaz Jundishapur University of Medical Sciences
Ahvaz Iran (Islamic Republic of) 6441945781 +98 61 3311 0000 Rostami_h@ajums.ac.ir Ahvaz University of Medical Sciences Iran (Islamic Republic of) Age range 18-65 Bipolar patients with obsessive compulsive comorbidity Consent of the patient's guardian 18 years 65 years Both F31 Bipolar disorder Treatment - Drugs Treatment - Drugs Intervention group: In addition to routine bipolar treatment, 10 mg (Shafa Company) Memantine tablets as one tablet after a detailed history and confirmation of the patient's obsession. Control group: In addition to the routine bipolar treatment, placebo tablets, which are similar to memantine tablets in terms of shape, smell, taste, size, and color, and are prepared by the Faculty of Pharmacy of Ahvaz University, are received in the same way as the intervention group. Obsession score. Timepoint: Before the intervention, 3, and 6 weeks after the intervention. Method of measurement: According to DSM-5 criteria. Side effects of memantine. Timepoint: During the study, 3, and 6 weeks after the intervention. Method of measurement: Physical examination. Ahvaz University of Medical Sciences Approved 2024-01-06 Ethics Committee of Jundi Shapur Ahvaz University of Medical Sciences Golestan St., Esfand St., Ahvaz Jundishapur University of Medical Sciences Ahvaz Khouzestan Iran (Islamic Republic of)