IRCT201108117295N1 IRCT 2012-02-16 Vice chancellor for research, Tabriz University of Medical Sciences The role of insulin therapy in reducing critical illness polyneuropathy and myopathy in pediatric intensive care unit The role of insulin therapy in reducing critical illness polyneuropathy and myopathy in pediatric intensive care unit 2010-09-23 anticipated 30 Complete https://irct.ir/trial/7743 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. 2-3 polyneuropathy and myopathy. Intervention 1: In this study,during one year and a half,30 of patients admitted to the pediatric intensive care unit of Tabriz Children's Hospital and are more than one week under mechanical ventilation and in the course of their hospitalization experience hyperglycemia (more than 180 milligram per decilitre) are divided into two groups; In first group with 15 patients,in which the intervention is done, insulin is used in order to keep blood sugar in range of 140-180 milligram per decilitre (until the patient is connected to the ventilator).Appropriate protocol will be continuous injection of 0.5 unit per kilogram insulin as drip with serial control of blood sugar each hour with the goal of keeping blood sugar between 140-180 milligram per decilitre. Note that the injection will be as same as first group and will be done by a person with no information about polymyopathy and neuropathy. Intervention 2: In second group with 15 patients which is called control group,distilled water as placebo will be used.Appropriate protocol in using distilled water,like insulin injection in intervened group,is continuous injection of 0.5 unit per kilogram insulin as drip with serial control of blood sugar each hour.Note that the injection will be done by a person with no information about polyneuropathy and myopathy and the injected substance.