]>
IRCT201405217327N4 IRCT 2014-09-30 Student Research Committee Comparison of the efficacy of intravenous paracetamol versus intravenous dexamethasone and intravenous morphine for the emergency department treatment of acute migraine headache Comparison of the efficacy of intravenous paracetamol versus intravenous dexamethasone and intravenous morphine for the emergency department treatment of acute migraine headache 2014-06-22 anticipated 270 Complete https://irct.ir/trial/7775 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Subjects will be randomized by Random.com website. N/A Acute migraine headache. Intervention 1: Intervention group: 1 gram acetaminophen will be soluted in 100 cc normal saline and will be infused in 10 minutes as a single dose. Drug name: Apotel, 1 g/6.7ml Chemical compound: Acetaminophen Company: Uni Pharma S.A country: Greece. Intervention 2: Control group: Morphine with 0.1 mg/kg dosage will be soluted in 100 cc normal saline and will be infused in 10 minutes as a single dose in order to simulation. Drug name: Morphin, 10 mg/ml Injection Chemical compound: Morphine sulfate company: Darou Pakhsh-Iran Country: Iran. Intervention 3: Control group: 8 milligram dexamethasone will be soluted in 100 cc normal saline and will be infused in 10 minutes as a single dose in order to simulation. Drug name: Dexamethasone, 8 mg/ml Chemical compound: Dexamethasone Company: Raha Co Isfahan-Iran Country: Iran.
public Dr.Samad Shams Vahdati
Emergency Medicine Department,Tabriz Imam Reza Hospital
Tabriz Iran (Islamic Republic of) +98 914 115 6941 Shams@tbzmed.ac.ir Tabriz University of Medical Sciences scientific Dr.Samad Shams Vahdati
Emergency Medicine Department,Tabriz Imam Reza Hospital
Tabriz Iran (Islamic Republic of) +98 41 1335 2078 shams@tbzmed.ac.ir Tabriz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria : the patients between 18 and 60 year old without any history of neurologic disorder with at least one experience of migraine headache and 4 criteria of 12 criteria of Vascular symptoms. Exclusion criteria : pregnancy; history of neurologic disorder; patients without self consent; Body temperature more than 37.7 C; diastolic blood pressure more than 105 mm Hg. no limit no limit Both G43 Migraine Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group: 1 gram acetaminophen will be soluted in 100 cc normal saline and will be infused in 10 minutes as a single dose. Drug name: Apotel, 1 g/6.7ml Chemical compound: Acetaminophen Company: Uni Pharma S.A country: Greece Control group: Morphine with 0.1 mg/kg dosage will be soluted in 100 cc normal saline and will be infused in 10 minutes as a single dose in order to simulation. Drug name: Morphin, 10 mg/ml Injection Chemical compound: Morphine sulfate company: Darou Pakhsh-Iran Country: Iran Control group: 8 milligram dexamethasone will be soluted in 100 cc normal saline and will be infused in 10 minutes as a single dose in order to simulation. Drug name: Dexamethasone, 8 mg/ml Chemical compound: Dexamethasone Company: Raha Co Isfahan-Iran Country: Iran Pain intensity of the acute migrane head ache. Timepoint: Before treatment, 10 minutes after the begining of treatment, 20 minutes after the begining of the treatment, 30 minutes after the begining of the treatment, 24 hours after the begining of the treatment. Method of measurement: Visual analoge score, Intensity of the pain in proportion to millimetr from 0 to 100 will be measured. Student Research Committee Approved 2014-02-05 Tabriz University of Medical Scinces Ethic Committe Central building number 2, Tabriz University of Medical Scinces, Golgasht street, Tabriz Tabriz Iran (Islamic Republic of)