IRCT20151219025600N5 IRCT 2024-07-24 Oroumia University of Medical Sciences Bolus dose of dexmedetomidine effect on hemodynamic response to laryngoscopy SBP,DBP,MAP,HR Studying the bolus dose of Dexmedetomidine effect in attenuating hemodynamic stress response to laryngoscopy and tracheal intubation in hypertensive patients 2024-07-31 anticipated 70 Complete https://irct.ir/trial/77780 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Other, Purpose: Treatment, Other design features: no more explanation, Randomization description: The patients by block randomization will be allocated to equal groups of study and placebo using "random allocation" software providing computerized numbers. The numbers will be written on envelopes containing the drug or placebo notes and will be delivered to the anesthesia nurse as sealed, Blinding description: The patient and the researcher who evaluates the outcomes will not informed of patients allocation to the study and control groups. Both drug and placebo will be colorless prepared and injected in 50 cc syringes at equal volumes. Each patient will allocate a number using randomization allocation software in sealed envelopes containing the drug or placebo delivered to the anesthesia nurse. The researcher will not be informed of syringe content. 3 Arterial Blood Pressure. Intervention 1: Intervention group:Patients without or with hypertension class I-II at age 40-70. Intervention 2: Control group: Patients without or with hypertension class I-II at age 40-70 receiving placebo (normal saline infusion). Yes - There is a plan to make this available What will be shared: Demographic and primary outcome data without identification can be shared. When: Research data will be available until April 2025 and there after. To whom: Only medical academic researchers have access to data. Conditions: No other condition is necessary for access. Where to obtain: Correspondent researcher Shahram Shokoohi shokohi.sh@umsu.ac.ir How to obtain: Write to the corresponding researcher Shahram Shokoohi shokohi.sh@umsu.ac.ir Comments: no more explanation