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IRCT201108177358N1 IRCT 2012-08-22 Arak university of medical sciences Effect of atorvastatin on blood sugar metabolism Therapeutic effects of atorvastatin on blood sugar, insulin resistance and inflammatory mediators in patients with diabetes type 2 2011-09-23 anticipated 88 Complete https://irct.ir/trial/7808 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Non-insulin-dependent diabetes mellitus. Intervention 1: In control group 44 type two diabetic patients took placebo one capsul daily for 12 weeks in addition to their medications and tests performed at begining and after trial. Intervention 2: In case group 44 patients with type two diabetes mellitus took atorvastatin 40 miligram daily for 12 weeks in addition to their medications and tests performed at begining and after tial.
public Dr.Mehdi Mahmudpour
Amir-Al-Momenin hospital
Arak Iran (Islamic Republic of) +98 86 1417 3630 mmahmudpour_59@yahoo.com Arak university of medical sciences scientific Dr.Afsane Talaeii
Amir-Al-Momenin hospital
Arak Iran (Islamic Republic of) +98 86 1417 3630 afsanehtalaeii@yahoo.com Assistant professor Iran (Islamic Republic of) inclusion criteria: The patients with diabetes type 2 who had Hb A1C less than 9, triglyceride less than 250, low density lipoprotein ( LDL) between 70 to 160, high density lipoprotein (HDL) more than 35, total cholesterol less than 240 and are treated with oral hypoglycemic agents. exclusion criteria: Evidence of diabetes complications such as retinopathy, nephropathy and Glomerular Filtration Rate(GFR) less than 60, cardiovascular involvement such as Congestive Heart Failure(CHF), Ischemic Heart Diseases(IHD), acute Myocardial Infarction (MI) during recent 1 year, history of epileptic disorders, history of significant active gastrointestinal diseases such as active peptic ulcer disease in recent 1 year, history of active significant hematologic , hepatic and musculoskeletal diseases , patients who treated with insulin, patients who affected to acute illness, allergic history to statins, history of alcohol and opium consumption, breast feeder mothers and pregnant patients, patients who have consumed statins during recent 6 months. no limit no limit Both E11 Non-insulin-dependent diabetes mellitus Treatment - Drugs Treatment - Drugs In control group 44 type two diabetic patients took placebo one capsul daily for 12 weeks in addition to their medications and tests performed at begining and after trial. In case group 44 patients with type two diabetes mellitus took atorvastatin 40 miligram daily for 12 weeks in addition to their medications and tests performed at begining and after tial TNF-alpha. Timepoint: befor starting trial and 3 months later. Method of measurement: serologic methods. HsCRP. Timepoint: befor starting trial and 3 months later. Method of measurement: serologic methods. FBS. Timepoint: befor starting trial and 3 months later. Method of measurement: serologic methods. Insulin. Timepoint: befor starting trial and 3 months later. Method of measurement: serologic methods. Leptin. Timepoint: befor starting trial and 3 months later. Method of measurement: serologic methods. Adiponektin. Timepoint: befor starting trial and 3 months later. Method of measurement: serologic methods. Side effects on liver enzymes. Timepoint: befor starting trial and 3 months later. Method of measurement: serologic methods. Side effects on muscle enzymes. Timepoint: befor starting trial and 3 months later. Method of measurement: serologic methods. Arak university of medical sciences Approved 2011-06-14 Arak University Of Medical Sciences Sardasht, Arak Arak Iran (Islamic Republic of)