IRCT20240805062662N1 IRCT 2024-08-31 Ahvaz University of Medical Sciences The effect of agomelatine on positive and negative symptoms of schizophrenic patients Evaluating the effect of agomelatine on positive and negative symptoms of schizophrenic patients admitted to the psychiatry ward of Golestan hospital 2024-09-05 anticipated 22 Complete https://irct.ir/trial/78425 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: To the patients randomly and by the method of randomized permutation blocks with a block size of 6 (using the table related to random permutations). A statistician will prepare a random list. The interventions used in this research will be placed in sealed envelopes according to the randomized list by someone outside the study according to the corresponding codes, and then each patient who will enter the study; will be assigned, Blinding description: The treating psychiatrist, nurse student evaluator and patients are not aware of the intervention and control group. 1-2 Schizophrenia. Intervention 1: Intervention group: In addition to the prescribed antipsychotic treatment that they were already taking, patients receive agomelatine tablets (Tadbir Kalaye Jam Pharmaceutical Company) in the form of one 25 mg tablet 30 minutes before going to sleep. Intervention 2: Control group: In addition to prescribed antipsychotic treatment, patients receive placebo tablets, which are similar to agomelatine tablets in terms of shape, smell, taste, size, and color, and are prepared by the Faculty of Pharmacy of Ahvaz University, in the same way as the intervention group. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information