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IRCT20240804062631N2 IRCT 2024-10-08 Kerman University of Medical Sciences evaluation of the effect of aloe vera and cinnamon on moisture absorption in oral mucosa Evaluation of the effect of aloe vera and cinnamon on stimulation and moisture absorption in oral mucosa: A double-blind clinical trial 2024-09-07 anticipated 80 Complete https://irct.ir/trial/78489 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization method and description of each method: block randomization Randomization Unit: Individual For randomization, one letter from A, B, C, D is assigned to each group. Then 76 envelopes containing one of the 4 letters A, B, C, D are prepared in the number of 19 for each group and are placed inside a box. When each person enters the study, an envelope is randomly selected and opened. and the person is assigned to that group. The study groups will remain confidential until after the analysis of the study results, Blinding description: In order to blind the researcher and volunteers to participate in the study, the sprays are numbered with numbers one to four. Barij essence is added to all groups to equalize the smell and taste. 2-3 XEROSTOMIA. Intervention 1: The first intervention group: aloe vera extract spray, Three times a day, 3 puffs of spray each time for two weeks, This spray is prepared by a doctor of pharmacy who is the pharmaceutical consultant of the present project at the research center for oral and dental diseases. Intervention 2: The second intervention group: cinnamon extract spray, Three times a day, 3 puffs of spray each time for two weeks,This spray is prepared by a doctor of pharmacy who is the pharmaceutical consultant of the present project at the research center for oral and dental diseases. Intervention 3: The third intervention group: Spray an equal solution of cinnamon and aloe vera, three times a day, Three times a day, 3 puffs of spray each time for two weeks, This spray is prepared by a doctor of pharmacy who is the pharmaceutical consultant of the present project at the research center for oral and dental diseases. Intervention 4: Control group: Normal saline spray, Three times a day, 3 puffs of spray each time for two weeks, This spray is prepared by a doctor of pharmacy who is the pharmaceutical consultant of the present project at the research center for oral and dental diseases. Yes - There is a plan to make this available What will be shared: Participant data file, part of the data such as information related to the main outcome. When: The access period starts 6 months after the publication of the article To whom: Public access after publication of the article Conditions: Using the data published in the article citing the article Where to obtain: Correspondence with the corresponding author Shahla Kakoei 09131408974 skakoei@gmail.com How to obtain: The applicant can correspond with the responsible author through email. Comments:
public Sina Kakooei
Kosar Blvd-Kerman
Kerman Iran (Islamic Republic of) 7616913555 +98 34 3211 3736 kakooei.s@gmail.com Kerman University of Medical Sciences scientific Shahla Kakoei
Kosar Blvd-Kerman
Kerman Iran (Islamic Republic of) 7616913555 +98 34 3211 3736 skakoei@gmail.com Kerman University of Medical Sciences Iran (Islamic Republic of) Patients 18 years and older Visiting the Faculty of Dentistry 18 years no limit Both Pregnancy Allergy to cinnamon or aloe vera History of radiotherapy and chemotherapy Uncontrolled chronic disease HIV, hepatitis C or hepatitis B infection R68.2 Dry mouth, unspecified Treatment - Drugs Treatment - Drugs Treatment - Drugs Other The first intervention group: aloe vera extract spray, Three times a day, 3 puffs of spray each time for two weeks, This spray is prepared by a doctor of pharmacy who is the pharmaceutical consultant of the present project at the research center for oral and dental diseases The second intervention group: cinnamon extract spray, Three times a day, 3 puffs of spray each time for two weeks,This spray is prepared by a doctor of pharmacy who is the pharmaceutical consultant of the present project at the research center for oral and dental diseases The third intervention group: Spray an equal solution of cinnamon and aloe vera, three times a day, Three times a day, 3 puffs of spray each time for two weeks, This spray is prepared by a doctor of pharmacy who is the pharmaceutical consultant of the present project at the research center for oral and dental diseases Control group: Normal saline spray, Three times a day, 3 puffs of spray each time for two weeks, This spray is prepared by a doctor of pharmacy who is the pharmaceutical consultant of the present project at the research center for oral and dental diseases Determining the effect of aloe vera and cinnamon on stimulating and moisturizing the oral mucosa. Timepoint: Oral saliva measurement at the beginning of the study (before the start of the intervention) and 14 days after the start of cinnamon and aloe vera spray. Method of measurement: Spitting test. Kerman University of Medical Sciences Approved 2024-08-13 Ethics committee of Kerman University of Medical Sciences Jahad Ave Kerman Kerman Iran (Islamic Republic of)