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IRCT20240830062905N1 IRCT 2024-09-23 Watim Medical and Dental College Effect of Premedication with Ibuprofen and Dexamethasone on Success Rate of Inferior Alveolar Nerve Block for Teeth with Irreversible Pulpitis: A Randomized Clinical Trial Effect of Premedication with Ibuprofen and Dexamethasone on Success Rate of Inferior Alveolar Nerve Block for Teeth with Irreversible Pulpitis: A Randomized Clinical Trial 2023-06-01 anticipated 60 Complete https://irct.ir/trial/78833 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: A total of 60 patients requiring treatment for irreversible pulpitis were randomly assigned into two groups : Ibuprofen 400 mg or Dexamethasone 0.5mg (30 patients in each group). Patients were allocated to the medication group randomly using computer generated random number table. Aside from the case selection, all the clinical procedures were executed by a single endodontist (who was not part of the study process) and had no involvement with the study outcome, Blinding description: To ensure blinding, neither the patient nor the operator had knowledge about the medication used as all medications were removed from their original containers and placed in new ones. In addition, allocation sequence was concealed from researchers who were part of the study to reduce bias. The patients were divided into two groups according to the selection used for medication: Group A (Ibuprofen 400 mg) or Group B (Dexamethasone 0.5mg), with 30 patients in each group. 3 Patients with irreversible pulpitis. Intervention 1: Intervention group-1: Dexamethasone with single dose of 0.5mg was given orally one hour prior to Inferior alveolar nerve block injections (IANB). Intervention 2: Intervention group-2: Ibuprofen with single dose of 400 mg was given orally one hour prior to Inferior alveolar nerve block injections (IANB). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Sadaf Amjad
11b, street 28, block F, naval anchorage, Islamabad
Islamabad Pakistan 46000 +92 300 5126514 sadafamjad986@gmail.com Watim Medical and Dental College, Rawalpindi scientific Sadaf Amjad
11b, street 28, block F, naval anchorage, Islamabad
Islamabad Pakistan 46000 +92 300 5126514 sadafamjad986@gmail.com Watim Medical and Dental College, Rawalpindi Pakistan patients with pain (VAS≥114) in mandibular molar having irreversible pulpitis confirmed by cold test using ethyl chloride, patients who were not taking any antibiotics, anti-inflammatory or analgesics for at least one-week prior to treatment. Both males and females were included age 18-60 years. 18 years 60 years Both 1. Patients with any known allergies Patients with a history of active peptic ulcer Patients with osteoporosis Pregnant or breast-feeding females Patients with immunosuppression K04.0 Pulpitis Treatment - Drugs Treatment - Drugs Intervention group-1: Dexamethasone with single dose of 0.5mg was given orally one hour prior to Inferior alveolar nerve block injections (IANB) Intervention group-2: Ibuprofen with single dose of 400 mg was given orally one hour prior to Inferior alveolar nerve block injections (IANB) Pain reduction. Timepoint: before and after 4 hours after the treatment. Method of measurement: Analogue Pain scale (VAS≤3) with scoring 1-10. Watim Medical and Dental College Approved 2023-05-03 Ethical committee of Watim medical and dental college Watim medical and dental college, main G.T road, Near T-chowk, Rawat Pakistan Rawalpindi Punjab Pakistan