<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE trials [
<!ELEMENT trials (trial+)>

<!ELEMENT trial (main,contacts,countries,criteria,health_condition_code,health_condition_keyword,intervention_code,
          intervention_keyword,primary_outcome,secondary_outcome,secondary_sponsor,secondary_ids,source_support,ethics_reviews)>

<!ELEMENT main (trial_id,utrn?,reg_name,date_registration,primary_sponsor,public_title,acronym?,scientific_title,scientific_acronym?,
          date_enrolment,type_enrolment,target_size,recruitment_status,url?,study_type,study_design,phase,hc_freetext?,i_freetext?,results_actual_enrolment,results_date_completed,results_url_link,results_summary,           results_date_posted,results_date_first_publication,results_baseline_char,results_participant_flow,results_adverse_events,results_outcome_measures,results_url_protocol,results_IPD_plan, results_IPD_description)>
<!ELEMENT trial_id (#PCDATA)>
<!ELEMENT utrn (#PCDATA)>
<!ELEMENT reg_name (#PCDATA)>
<!ELEMENT date_registration (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT primary_sponsor (#PCDATA)>
<!ELEMENT public_title (#PCDATA)>
<!ELEMENT acronym (#PCDATA)>
<!ELEMENT scientific_title (#PCDATA)>
<!ELEMENT scientific_acronym (#PCDATA)>
<!ELEMENT date_enrolment (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT type_enrolment (#PCDATA)>
<!ELEMENT target_size (#PCDATA)>
<!ELEMENT recruitment_status (#PCDATA)><!-- Pending,Recruiting,Suspended,Complete,Other -->
<!ELEMENT url (#PCDATA)>
<!ELEMENT study_type (#PCDATA)><!-- interventional,observational -->
<!ELEMENT study_design (#PCDATA)>
<!ELEMENT phase (#PCDATA)>
<!ELEMENT hc_freetext (#PCDATA)>
<!ELEMENT i_freetext (#PCDATA)>
<!ELEMENT results_actual_enrolment (#PCDATA)>
<!ELEMENT results_date_completed (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_url_link (#PCDATA)>
<!ELEMENT results_summary (#PCDATA)>
<!ELEMENT results_date_posted (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_date_first_publication (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_baseline_char (#PCDATA)>
<!ELEMENT results_participant_flow (#PCDATA)>
<!ELEMENT results_adverse_events (#PCDATA)>
<!ELEMENT results_outcome_measures (#PCDATA)>
<!ELEMENT results_url_protocol (#PCDATA)>
<!ELEMENT results_IPD_plan (#PCDATA)>
<!ELEMENT results_IPD_description (#PCDATA)>


<!ELEMENT contacts (contact+)>
<!ELEMENT contact (type,firstname,middlename,lastname,address,city,country1,zip,telephone,email,affiliation)>
<!ELEMENT type (#PCDATA)><!-- Public,Scientific -->
<!ELEMENT firstname (#PCDATA)>
<!ELEMENT middlename (#PCDATA)>
<!ELEMENT lastname (#PCDATA)>
<!ELEMENT address (#PCDATA)>
<!ELEMENT city (#PCDATA)>
<!ELEMENT country1 (#PCDATA)>
<!ELEMENT zip (#PCDATA)>
<!ELEMENT telephone (#PCDATA)>
<!ELEMENT email (#PCDATA)>
<!ELEMENT affiliation (#PCDATA)>

<!ELEMENT countries (country2+)>
<!ELEMENT country2 (#PCDATA)>

<!ELEMENT criteria (inclusion_criteria,agemin,agemax,gender,exclusion_criteria)>
<!ELEMENT inclusion_criteria (#PCDATA)>
<!ELEMENT agemin (#PCDATA)>
<!ELEMENT agemax (#PCDATA)>
<!ELEMENT gender (#PCDATA)>
<!ELEMENT exclusion_criteria (#PCDATA)>

<!ELEMENT health_condition_code (hc_code+)>
<!ELEMENT hc_code (#PCDATA)>

<!ELEMENT health_condition_keyword (hc_keyword+)>
<!ELEMENT hc_keyword (#PCDATA)>

<!ELEMENT intervention_code (i_code+)>
<!ELEMENT i_code (#PCDATA)>

<!ELEMENT intervention_keyword (i_keyword+)>
<!ELEMENT i_keyword (#PCDATA)>

<!ELEMENT primary_outcome (prim_outcome+)>
<!ELEMENT prim_outcome (#PCDATA)>

<!ELEMENT secondary_outcome (sec_outcome+)>
<!ELEMENT sec_outcome (#PCDATA)>

<!ELEMENT secondary_sponsor (sponsor_name+)>
<!ELEMENT sponsor_name (#PCDATA)>

<!ELEMENT secondary_ids (secondary_id+)>
<!ELEMENT secondary_id (sec_id,issuing_authority)>
<!ELEMENT sec_id (#PCDATA)>
<!ELEMENT issuing_authority (#PCDATA)>

<!ELEMENT source_support (source_name+)>
<!ELEMENT source_name (#PCDATA)>

<!ELEMENT ethics_reviews (ethics_review+)>
<!ELEMENT ethics_review (status,approval_date,contact_name,contact_address,contact_phone,contact_email)>
<!ELEMENT status (#PCDATA)><!-- Not approved,Approved,NA -->
<!ELEMENT approval_date (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT contact_name (#PCDATA)>
<!ELEMENT contact_address (#PCDATA)>
<!ELEMENT contact_phone (#PCDATA)>
<!ELEMENT contact_email (#PCDATA)>
]>
<trials>
  <trial>
    <main>
      <trial_id>IRCT201207187457N10</trial_id>
      <utrn></utrn>
      <reg_name>IRCT</reg_name>
      <date_registration>2012-10-08</date_registration>
      <primary_sponsor>BMN (Bonyad Melli Nokhbegan)</primary_sponsor>
      <public_title>Importance of Mini-laparoscopy in kidney donation</public_title>
      <acronym></acronym>
      <scientific_title>Comparison of efficacy and safety of mini-laparoscopy and standard laparoscopy in kidney donors</scientific_title>
      <scientific_acronym></scientific_acronym>
      <date_enrolment>2012-08-21</date_enrolment>
      <type_enrolment>anticipated</type_enrolment>
      <target_size>100</target_size>
      <recruitment_status>Complete</recruitment_status>
      <url>https://irct.ir/trial/7915</url>
      <study_type>interventional</study_type>
      <study_design>Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Kind of randomization: Simple random sampling.</study_design>
      <phase>2</phase>
      <hc_freetext>Renal failure (kidney donation to patients with ESRD).</hc_freetext>
      <i_freetext>Intervention 1: Control group: 50 patients who underwent laparoscopic standard donor nephrectomy  &#13;
Laparoscopic standard nephrectomy: this operation is performed using one 12 mm port for video scope, two 5 mm for grasping and scissoring and one 10 mm port for vascular clipping. The specimen is extracted from pfananestiel incision. Intervention 2: Intervention group: 50 patients who underwent donor nephrectomy using mini-laparoscopic approach.&#13;
Mini-laparoscopic approach: This operation is performed using two 3.5 mm ports for grasping and scissoring, one 5 mm port for video scope and one 10 mm port in the pfanenstiel incision.</i_freetext>
      <results_actual_enrolment></results_actual_enrolment>
      <results_date_completed></results_date_completed>
      <results_url_link></results_url_link>
      <results_summary></results_summary>
      <results_date_posted></results_date_posted>
      <results_date_first_publication></results_date_first_publication>
      <results_baseline_char></results_baseline_char>
      <results_participant_flow></results_participant_flow>
      <results_adverse_events></results_adverse_events>
      <results_outcome_measures></results_outcome_measures>
      <results_url_protocol></results_url_protocol>
      <results_IPD_plan></results_IPD_plan>
      <results_IPD_description></results_IPD_description>
    </main>
    <contacts>
      <contact>
        <type>public</type>
        <firstname>Mohammad Hossein Soltani</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>No#99, Boostan 9th St., Pasdaran Ave.</address>
        <city>Tehran</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip></zip>
        <telephone>+98 21 2258 8016</telephone>
        <email>mhsoltani@iurtc.org.ir</email>
        <affiliation>Shahid Labbafinejad Medical Center</affiliation>
      </contact>
      <contact>
        <type>scientific</type>
        <firstname>Nasser Simforoosh</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>No#99, Boostan 9th St., Pasdaran Ave.</address>
        <city>Tehran</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip></zip>
        <telephone>+98 21 2258 8016</telephone>
        <email>simforoosh@iurtc.org.ir</email>
        <affiliation>Shahid Labbafinejad Medical Center</affiliation>
      </contact>
    </contacts>
    <countries>
      <country2>Iran (Islamic Republic of)</country2>
    </countries>
    <criteria>
      <inclusion_criteria>Inclusion criteria:&#13;
The cases who candidate for laparoscopic donor nephrectomy.&#13;
&#13;
Exclusion criteria:&#13;
Right donor nephrectomy, vascular anomaly, previous history of laparotomy</inclusion_criteria>
      <agemin>18 years</agemin>
      <agemax>45 years</agemax>
      <gender>Both</gender>
      <exclusion_criteria></exclusion_criteria>
    </criteria>
    <health_condition_code>
      <hc_code>N17- N18 -</hc_code>
    </health_condition_code>
    <health_condition_keyword>
      <hc_keyword>Kidney damage with severely decreased GFR (15-29 mL/min)</hc_keyword>
    </health_condition_keyword>
    <intervention_code>
      <i_code>Treatment - Surgery</i_code>
      <i_code>Treatment - Surgery</i_code>
    </intervention_code>
    <intervention_keyword>
      <i_keyword>Control group: 50 patients who underwent laparoscopic standard donor nephrectomy  &#13;
Laparoscopic standard nephrectomy: this operation is performed using one 12 mm port for video scope, two 5 mm for grasping and scissoring and one 10 mm port for vascular clipping. The specimen is extracted from pfananestiel incision.</i_keyword>
      <i_keyword>Intervention group: 50 patients who underwent donor nephrectomy using mini-laparoscopic approach.&#13;
Mini-laparoscopic approach: This operation is performed using two 3.5 mm ports for grasping and scissoring, one 5 mm port for video scope and one 10 mm port in the pfanenstiel incision.</i_keyword>
    </intervention_keyword>
    <primary_outcome>
      <prim_outcome>Warm ischemic time. Timepoint: During operation. Method of measurement: From renal artery clamping to beginning of cold saline irrigation.</prim_outcome>
      <prim_outcome>Hemoglobin. Timepoint: Before operation - the day after operation - at discharge time. Method of measurement: Laboratory test (CBC).</prim_outcome>
      <prim_outcome>Admission time. Timepoint: From operation to discharge. Method of measurement: Number of admission day.</prim_outcome>
      <prim_outcome>Appearance of trocars scar. Timepoint: Three months after operation. Method of measurement: Observation and determination of scars.</prim_outcome>
      <prim_outcome>GFR in recipient. Timepoint: Three months after operation. Method of measurement: Kortchof formula.</prim_outcome>
      <prim_outcome>Blood pressure in donor. Timepoint: Three months after operation. Method of measurement: Using assessment of blood pressure.</prim_outcome>
    </primary_outcome>
    <secondary_outcome>
      <sec_outcome>Bleeding. Timepoint: During operation and in recovery room. Method of measurement: Regarding to the measurement of blood extracted from the suction.</sec_outcome>
      <sec_outcome>Requirement to analgesic and opium. Timepoint: In recovery room and unit admission. Method of measurement: Assessment of dose injected IM or IV.</sec_outcome>
      <sec_outcome>Visceral injury. Timepoint: During operation. Method of measurement: According to direct vision of injury or delayed manifestations in postoperative days.</sec_outcome>
    </secondary_outcome>
    <secondary_sponsor>
      <sponsor_name>Urology and Nephrology Research Center, Vice chancellor for research of Shahid Behesti University of</sponsor_name>
    </secondary_sponsor>
    <secondary_ids>
      <secondary_id>
        <sec_id></sec_id>
        <issuing_authority></issuing_authority>
      </secondary_id>
    </secondary_ids>
    <source_support>
      <source_name>BMN (Bonyad Melli Nokhbegan)</source_name>
      <source_name>Urology and Nephrology Research Center, Vice chancellor for research of Shahid Behesti University of</source_name>
    </source_support>
    <ethics_reviews>
      <ethics_review>
        <status>Approved</status>
        <approval_date>2012-05-31</approval_date>
        <contact_name>Urology and Nephrology Research Center (UNRC) related to Shahid Beheshti Medical University (SBMU)</contact_name>
        <contact_address>No#103, 9th Boostan St., Pasdaran Ave. Tehran  Iran (Islamic Republic of)</contact_address>
        <contact_phone></contact_phone>
        <contact_email></contact_email>
      </ethics_review>
    </ethics_reviews>
  </trial>
</trials>
