IRCT201605257513N12 IRCT 2016-07-22 Vice chancelor of research of Isfahan University of Medical Sciences Comparison the effect of Metformin and Rosiglitazone, alone and in combination, to treat polycystic ovary syndrome. Investigation and comparison of the effect of metformin and rosiglitazone alone and in combination on ovarian and endometrium among polycystic ovarian syndrome patients 2013-03-20 anticipated 44 Complete https://irct.ir/trial/8001 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Crossover, Purpose: Treatment, Other design features: Since the list of patients is available, 44 patients of these two centers will be selected by simple random sampling method. Then the name of each patient will be separately written on a card, and 22 cards will be chosen randomly. These patients will receive the first intervention and those remaining patients will be assigned into second intervention. 2 Polycystic ovarian syndrome. Intervention 1: Metformin intervention group: Patients well be followed without any drug for the first 6 weeks. Then they will receive metformin alone for 12 weeks. After that they will receive the combination of metformin and rosiglitasone for 12 weeks. Intervention 2: Rosiglitazone intervention group: Patients well be followed without any drug for the first 6 weeks. Then they will receive rosiglitazone alone for 12 weeks. After that they will receive the combination of metformin and rosiglitasone for 12 weeks.