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IRCT20241108063640N2 IRCT 2024-11-15 Oroumia University of Medical Sciences Comparing the effect of dexmetedomidine and remifentanil on controlled hypotension in patients undergoing general anesthesia candidates for spine surgery Comparing the effect of dexmetedomidine and remifentanil on controlled hypotension in patients undergoing general anesthesia candidates for spine surgery 2024-12-20 anticipated 70 Complete https://irct.ir/trial/80076 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: . Adult patients with ASA I-II status undergoing spinal surgery under general anesthesia in Imam Khomeini Hospital Urmia will be included in the study. Then the patients will be divided into two groups of dexmedetomidine and remifentanil (35 people in each group) using the table of random numbers, Randomization description: Patients will be randomly divided into two groups based on random numbers generated using Random Allocation computer software, Blinding description: The patient and the trained technician are responsible for recording the patients' data and will not be informed about the grouping of the drugs used. 1-2 Adult patients with ASA I-II status undergoing spine surgery under general anesthesia. Intervention 1: Intervention group: Dexmedetomidine group. Intervention 2: Intervention group: Fentanyl withdrawal group. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is After finishing the design and according to the results, I will decide to publish
public Dr.Hadi Hooshyar
Imam Khomeini University Hospital-Ershad AVE-Modarres Blvd- Urmia
Urmia Iran (Islamic Republic of) 5715789397 +98 44 3346 9931 hooshyarhadi@gmail.com Oroumia University of Medical Sciences scientific Dr.Hadi Hooshyar
Imam Khomeini University Hospital-Ershad AVE-Modarres Blvd- Urmia
Urmia Iran (Islamic Republic of) 5715789397 +98 44 3346 9931 hooshyarhadi@gmail.com Oroumia University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria included adult patients with ASA I-II status undergoing spine surgery under general anesthesia Completion of the informed consent form for participating in the study 18 years 65 years Both Patients who need emergency surgery Pregnant people Patients with a history of spine surgery History of opioid use Drug abuse or alcohol addiction History of neurological diseases Neuromuscular or psychiatric (especially history of seizures or epilepsy) History of heart failure patients with cardiac bradycardia Long-term and chronic use of pain relievers, including cyclooxygenase 2 inhibitorsPatients with unpredictable events such as severe bleeding Treatment - Drugs Treatment - Drugs Intervention group: Dexmedetomidine group Intervention group: Fentanyl withdrawal group Systolic and diastolic blood pressure control. Timepoint: (before induction), t1 (after induction), t2 (after incision), t3 (15 minutes after surgery), t9 (90 minutes after surgery), R0 (entering the recovery room) and R30 (30 minutes after from entering the recovery room). Method of measurement: by a non-invasive sphygmomanometer for anesthesia monitoring. Oroumia University of Medical Sciences Approved 2024-10-02 Ethics Committee of Imam Khomeini Hospital Imam Khomeini University Hospital-Ershad AVE-Modarres Blvd- Urmia Urmia West Azarbaijan Iran (Islamic Republic of)