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IRCT20240527061914N1 IRCT 2025-02-13 Tehran University of Medical Sciences Investigating the effect of isotretinoin along with itraconazole in the treatment of skin fungus Investigating the effect of isotretinoin along with itraconazole in the treatment of patients with dermatophytes 2024-12-12 anticipated 80 Complete https://irct.ir/trial/80128 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: block randomization The table of random numbers is used in such a way that a random number is generated at each stage. If the generated number is between 0 and 4, the patient is placed in the Isotretinoin and Itraconazole group, and if the number is between 5 and 9, the patient is placed in the Itraconazole group. Therefore, we repeat this process many times until eligible patients enter the study, Blinding description: Two groups of 40 people with dermatophytes are randomly treated with antifungal. The method of blinding is single blind, which means that the patient does not know the type of treatment (before starting the treatment, the patients will be ethically discussed and they will enter the study with full consent and knowledge). 3 Dermatophyte (fungal disease). Intervention 1: Intervention group: treated with itraconazole 100 mg every 12 hours and isotretinoin 20 mg every other day and sertaconazole ointment every 8 hours and shampoo ketoconazole 3 times a week. Intervention 2: Control group: treated with itraconazole 100 mg every 12 hours and sertaconazole ointment every 8 hours and shampoo ketoconazole 3 times a week. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Hajar Masoomi Farah abadi
Vesal Shirazi Street - between Italy Street and Parisi Ancient Alley - Vesal Hostel
Tehran Iran (Islamic Republic of) 1417743855 +98 911 329 0091 saramasoomi1376@gmail.com Tehran University of Medical Sciences scientific Dr. safoura shakoei nezhad
Vahdat Islamic St. - Razi Hospital
Tehran Iran (Islamic Republic of) 1199663911 +98 912 322 0757 dr.shakoei@gmail.com Tehran University of Medical Sciences Iran (Islamic Republic of) Patients who have been diagnosed with dermatophyte by Koh test 12 years 60 years Both Under 12 years Over 60 years old pregnant milked Has a history of diabetes Has a history of liver disease Has a history of kidney disease History of alcohol consumption B35.4 Tinea corporis Treatment - Drugs Treatment - Drugs Intervention group: treated with itraconazole 100 mg every 12 hours and isotretinoin 20 mg every other day and sertaconazole ointment every 8 hours and shampoo ketoconazole 3 times a week Control group: treated with itraconazole 100 mg every 12 hours and sertaconazole ointment every 8 hours and shampoo ketoconazole 3 times a week Comparison of the effect of isotretinoin on the treatment of dermatophytes. Timepoint: Examination at the beginning of the study and then monthly until the dermatophyte infection is completely resolved. Method of measurement: Clinical examination. Tehran University of Medical Sciences Approved 2024-10-28 Fatemeh Saeidi Keshavarz Blvd., Intersection of Qods St., Central Building of Tehran University of Medical Sciences Tehran Tehran Iran (Islamic Republic of)