IRCT20241127063872N1 IRCT 2025-01-02 Tabriz University of Medical Sciences Effect of Allogenic Demineralized Dentin Matrix (ADDM) on healing outcome in maxillary sinus floor augmentation The Effect of Allogenic Demineralized Dentin Matrix (ADDM) on healing outcome in maxillary sinus floor augmentation (Histological and Radiological examination):Clinical trial 2024-12-21 anticipated 38 Complete https://irct.ir/trial/80521 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: Patients do not know about control (Xenograft) and test (dentin graft). In order to blind the surgery, the first stage (dentin graft and Xenograft placement) and the second stage (sample collection and implant placement) will be performed by two surgeons. N/A Candidate patients for implant placement in the posterior region of the maxilla and maxillary sinus floor augmentation surgery. Intervention 1: **Intervention Group:**In the surgical procedure for the intervention group, 2 cc of allogenic demineralized dentin matrix is placed. Teeth with a poor prognosis (such as non-functioning third molars) and no root fillings are extracted. Soft tissue, debris, and cementum on the root surface are removed using a sickle scaler, and the pulp inside the root is extracted with a k-file; enamel is removed with a burr.The remaining dentin is rinsed with sterile saline and processed in a bone mill to create particles sized 1 to 1.5 mm. These particles are washed in a 0.1 M sodium chloride solution, treated with 0.1 M Tris-HCl (pH 7.4) for 10 minutes, and then demineralized in 2% HNO3 (pH 1.0).To acellularize the samples, trypsin, raffinose, and sucrose are used in Hanks buffer. Finally, the samples are washed three times with a PBS solution containing penicillin and streptomycin for 10 minutes each and then disinfected by UV. Intervention 2: Control group: In control surgery Xenograft (Bone +B; Nova Teb Pars, Marzanabad, Iran) is placed. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Due to the innovative nature of this research, the researchers have decided not to share the data. A final decision will be made after the data is collected.