IRCT20241204063947N1 IRCT 2025-02-04 Shahid Beheshti University of Medical Sciences Socket Preservation with Collagen and Its Impact on Post-Extraction Healing Clinical Evaluation of the Impact of Socket Preservation Using Collagen-Based Clot Retention Compared to Conventional Methods on Wound Healing Following Tooth Extraction in Patients Requiring Tooth Extraction 2017-07-23 anticipated 20 Complete https://irct.ir/trial/80703 interventional Randomization: Not randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Blinding description: The treatment boxes are sealed with 10-digit codes, and each code contains either the original treatment (clot-preserving collagen) or the alternative treatment (no clot-preserving collagen). The researcher will ensure that patients are completely unaware of their treatment by closely monitoring the treatment process. N/A Atraumatic tooth extraction, soft tissue healing. Intervention 1: Intervention group: The tooth extraction was performed conservatively and bilaterally. On one side, the dental socket was managed using natural collagen (Collacone, Botiss Biomaterials, Germany). For this purpose, after administering local anesthesia with (Persocaine-E; Daroupakhsh, Tehran, Iran), the periodontal ligaments were separated using a periosteal elevator, and the tooth was extracted conservatively using universal forceps (Aesculap Co, USA) with vertical and rotational pressure. In the intervention group, a piece of Collacone with dimensions (e.g., 10 × 10 × 5 mm, if specified) was placed inside the dental socket. The socket opening was then closed using 4-0 Vicryl absorbable sutures (Ethicon, Johnson & Johnson, NJ, USA) in a horizontal mattress technique. Intervention 2: Control group: The same surgical and suturing procedures were followed, but no collagen material was applied.Postoperative care instructions, including oral hygiene guidelines, dietary recommendations, and pain management with Gelofen (Ibuprofen 400 mg, Daana Pharma, Iran), were provided. Sutures were removed one week postoperatively. No - There is not a plan to make this available Justification or reason for not sharing IPD is We do not share the data. Individual participant data will not be published due to ethical considerations and patient privacy concerns.