IRCT20230202057310N16 IRCT 2025-01-22 Muhammad Institute of Medical and Allied Sciences, Multan Curcumin Gel Along With Ultrasound and Eccentric Exercises On Patellar Tendinopathy Management Formulation And Evaluation of Curcumin Gel Along With Ultrasound and Eccentric Exercises On Patellar Tendinopathy Management 2025-01-01 anticipated 90 Complete https://irct.ir/trial/80759 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The randomization process will be conducted using computer-generated random numbers to assign participants to treatment groups in a predefined allocation sequence. A stratified or block randomization approach will be used to ensure balance between groups for key variables (e.g., age, gender, baseline disease severity). Medications will be prepared and packaged in identical numbered white boxes according to the allocation sequence. Each box will have a unique medication number corresponding to the assigned treatment, ensuring blinding. The allocation sequence and treatment codes will be securely stored and accessible only to the principal investigator, who is not involved in participant interactions or outcome assessments, Blinding description: The statistical analyst and outcome assessor will be blinded to treatment allocation by using securely stored randomization codes, accessible only to an independent party. Data will be analyzed using anonymous identifiers, and group allocation will be revealed only after data collection and analysis are complete. This ensures minimization of bias. 2-3 Patellar Tendinopathy. Intervention 1: Intervention group: Group A (Eccentric Exercise + Curcumin–Aloe Vera Gel): Curcumin–aloe vera gel (2 g) will be applied topically to the patellar tendon, followed by a supervised eccentric exercise. The program included wall sits, Spanish squats, box squats, and reverse lunges. All exercises will perform in three sets of 15 repetitions each, at a controlled tempo of 3 seconds eccentric and 1 second concentric. Sessions occurred 4 times per week for 8 weeks, with progressive loading applied biweekly according to pain-free tolerance (0–3/10 NPRS during exercise). Intervention 2: Control group: Participants will receive2 g of curcumin–aloe vera gel apply topically over the patellar tendon and delivered transdermally using therapeutic ultrasound. Ultrasound will be administered at a frequency of 1 MHz, intensity of 1.5 W/cm², in pulsed mode for 10 minutes using a circular application technique. Treatment will be administered 4 times per week for 8 weeks. No eccentric exercise or other therapeutic exercise will be included in this group to isolate the effect of ultrasound-mediated transdermal delivery of the gel. Adherence will be monitored through clinic attendance registers and self-reported gel application logs. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is N/A