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IRCT20241026063497N1 IRCT 2025-05-13 Urmia University Comparison of effectiveness of interpretation bias correction training and acceptance and commitment therapy on patients with multiple sclerosis Comparison of effectiveness of interpretation bias correction training and acceptance and commitment therapy (ACT) on cognitive-behavioral and emotional symptoms of patients with multiple sclerosis (M.S). 2024-12-30 anticipated 54 Complete https://irct.ir/trial/80870 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: The randomization method was considered as simple randomization with individual random units. Subsequently, the final sample was divided into two experimental groups and one control group. The randomization process was carried out using the website www.randomization.com. N/A Multiple sclerosis. Intervention 1: Intervention group 1: Training in interpretation bias modification: In the present study, while providing necessary explanations to patients and ensuring the confidentiality of their information, patients are trained over 4 weeks with 2 individual sessions of 90 minutes each per week in the form of cognitive-behavioral therapy to identify their negative interpretations and then be able to reconstruct them into more logical interpretations. The term 'interpretation bias' in this research refers to individuals' tendency to interpret ambiguous and neutral events negatively and threateningly. This bias can manifest in various areas such as social relationships, health, and job performance. During therapy sessions, various cognitive-behavioral techniques are used, such as thought recording, Socratic questioning, identifying cognitive errors (especially errors related to interpretation), providing supporting and opposing evidence, creating alternative perspectives, and behavioral exercises. Intervention 2: Acceptance and Commitment Therapy: In the present study, while providing the necessary explanations to the group members and ensuring the confidentiality of their information, patients are treated in a group setting and over 4 weeks, with 2 sessions per week lasting 90 minutes, under Acceptance and Commitment Therapy. The content of these sessions includes the 6 main components of the Acceptance and Commitment approach, along with the use of metaphors related to the sessions and practical exercises. During the sessions, various metaphors are used to facilitate understanding of Acceptance and Commitment approach concepts. For example, the metaphor of "quicksand" is used to show that trying to control unpleasant thoughts and feelings can lead to becoming more submerged in them, the metaphor of the "bus" is used to show that thoughts and feelings are the passengers on the bus and the individual is the driver and can choose their route, and the metaphor of "tug-of-war with a monster" is used to show that fighting unpleasant thoughts and feelings takes a lot of energy and it is better to drop the rope. During the sessions, the therapist plays the role of a facilitator and helps the members to identify their values, set committed goals, and face their unpleasant experiences with more acceptance and flexibility. The therapist also provides a safe and supportive environment so that members can share their experiences and support each other. Intervention 3: Control group: In this study, no intervention is performed for the control group, and it is initially considered solely for measurement and observation purposes. Yes - There is a plan to make this available What will be shared: Pre-test, Post-test, Retention test When: 6 months after the results are published To whom: All researchers Conditions: Can be used for therapists in this field as well as researchers of review research, meta-analysis, etc. Where to obtain: Saleh Sadighi How to obtain: Official Request Letter. Comments:
public Saleh Sadighi
Mir building, 55.3 Side alley, 55 Darya, Kelkaser, Amol
Amol Iran (Islamic Republic of) 4617139606 +98 11 4308 0317 salehsadighi@gmail.com Urmia University scientific Saleh Sadighi
Mir building, 55.3 Side alley, 55 Darya, Kelakaser, Amol
Amol Iran (Islamic Republic of) 4617139606 +98 11 4308 0317 salehsadighi@gmail.com Urmia University Iran (Islamic Republic of) Must have a definitive diagnosis of multiple sclerosis. Must be at least 18 and at most 45 years old. Have at least a diploma. Damage in cognitive, behavioral and emotional symptoms examined in this research should be diagnosed by interview and test. 18 years 45 years Both Receive other concurrent treatment. The symptoms are due to drug use and bereavement. Have a history of receiving similar interventions. G35 Multiple sclerosis Rehabilitation Rehabilitation Rehabilitation Intervention group 1: Training in interpretation bias modification: In the present study, while providing necessary explanations to patients and ensuring the confidentiality of their information, patients are trained over 4 weeks with 2 individual sessions of 90 minutes each per week in the form of cognitive-behavioral therapy to identify their negative interpretations and then be able to reconstruct them into more logical interpretations. The term 'interpretation bias' in this research refers to individuals' tendency to interpret ambiguous and neutral events negatively and threateningly. This bias can manifest in various areas such as social relationships, health, and job performance. During therapy sessions, various cognitive-behavioral techniques are used, such as thought recording, Socratic questioning, identifying cognitive errors (especially errors related to interpretation), providing supporting and opposing evidence, creating alternative perspectives, and behavioral exercises. Acceptance and Commitment Therapy: In the present study, while providing the necessary explanations to the group members and ensuring the confidentiality of their information, patients are treated in a group setting and over 4 weeks, with 2 sessions per week lasting 90 minutes, under Acceptance and Commitment Therapy. The content of these sessions includes the 6 main components of the Acceptance and Commitment approach, along with the use of metaphors related to the sessions and practical exercises. During the sessions, various metaphors are used to facilitate understanding of Acceptance and Commitment approach concepts. For example, the metaphor of "quicksand" is used to show that trying to control unpleasant thoughts and feelings can lead to becoming more submerged in them, the metaphor of the "bus" is used to show that thoughts and feelings are the passengers on the bus and the individual is the driver and can choose their route, and the metaphor of "tug-of-war with a monster" is used to show that fighting unpleasant thoughts and feelings takes a lot of energy and it is better to drop the rope. During the sessions, the therapist plays the role of a facilitator and helps the members to identify their values, set committed goals, and face their unpleasant experiences with more acceptance and flexibility. The therapist also provides a safe and supportive environment so that members can share their experiences and support each other. Control group: In this study, no intervention is performed for the control group, and it is initially considered solely for measurement and observation purposes. Cognitive bias. Timepoint: Before the intervention, the last intervention session and 2 months after the last intervention session. Method of measurement: Cognitive bias questionnaire of Woody, Chambless and Glass. Profile of psychosis. Timepoint: Before the intervention, the last intervention session and 2 months after the last intervention session. Method of measurement: Depression, Anxiety, Stress Scale (DASS) Lavibond and Lavibond. Emotional information processing. Timepoint: Before the intervention, the last intervention session and 2 months after the last intervention session. Method of measurement: Emotional Information Processing Questionnaire Baker et al.'s. M.S self-efficacy. Timepoint: Before the intervention, the last intervention session and 2 months after the last intervention session. Method of measurement: Multiple Sclerosis Self-Efficacy Questionnaire (MSSS). Acceptance of illness. Timepoint: Before the intervention, the last intervention session and 2 months after the last intervention session. Method of measurement: Disease Acceptance Scale (ALS). Urmia University Approved 2024-05-18 Research Ethical Committee of Urmia University University of Urmia, 11 km Sero Road, Azerbaijangharbi Province - Urmia urmia West Azarbaijan Iran (Islamic Republic of)