IRCT20241228064194N1 IRCT 2025-04-20 Tehran University of Medical Sciences High power Laser in carpal tunnel syndrome Comparative Evaluation of High-power Laser versus Anti-Inflammatory Effects of Corticosteroid Injection on Symptoms and Function in Patients with Mild to Moderate Carpal Tunnel Syndrome 2025-05-05 anticipated 40 Complete https://irct.ir/trial/81027 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: randomized (block randomization method with the block size 4 using Excel software), phase 4 on 40 patients, Blinding description: This was a single-blind study. A physician (specialist in physical medicine and rehabilitation), who was unaware of the treatment group of each patient, was responsible for the initial electrodiagnostic assessment and for collecting data from all patients (including demographic data, pain intensity [VAS], Boston questionnaire, grip strength, and electrodiagnostic findings). Another physician performed high-power laser therapy, and a therapist administered the cortisone injections, both of whom were blinded to the patients’ group assignments. The patients themselves were not blinded to the treatment they received. N/A carpal tunnel syndrome. Intervention 1: Intervention group: Patients will receive six sessions of high-power laser therapy over three weeks, with a two-day interval between each session, each lasting five minutes, according to the predefined protocol on the Novin high-power laser device (30 Hz frequency, 1.5 W power, and 30 J/cm² dose). The device is calibrated before use and is the same for all patients. Due to the lack of consistency in laser parameters across studies using high-power lasers, we used the preset program for carpal tunnel syndrome (CTS) provided by the device. The session begins with the patient seated in a relaxed position, with the forearm resting on the treatment table. In the main unit of the device, the therapist selects the CTS treatment program. Then, after providing protective glasses for both the patient and therapist, the treatment begins, and the scanner probe is moved back and forth over the flexor retinaculum of the wrist (3 cm proximal and distal to the wrist crease) for five minutes, simultaneously with pedal pressure, which activates the laser. The pedal pressure corresponds to the laser exposure. All these steps are performed by one physician for all patients. Intervention 2: Control group: For this group of patients, routine and standard treatment for carpal tunnel syndrome is performed. This treatment includes an injection of 1 mL of triamcinolone (40 mg) in the distal wrist crease. No - There is not a plan to make this available Justification or reason for not sharing IPD is “There is no more information available.”