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IRCT201512077676N4 IRCT 2016-04-06 Vice Chancellor for Research and Technology University of Medical Sciences The effect of progesterone in patients with premature rupture of membranes The effect of progesterone in patients with premature rupture of membranes 2016-03-10 anticipated 120 Complete https://irct.ir/trial/8137 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. N/A Premature rupture of membranes, labour delayed by therapy. Intervention 1: Intervention group : progesterone ( 400 mg a daily intravaginal. Intervention 2: Control group: routine treatment includes injections of betamethasone 12 mg of progesterone administered every 12 hours.
public Dr.Simin Taghavi
Tabriz University of medical Sciences; Golgasht Street
Tabriz Iran (Islamic Republic of) +98 41 3553 9161 lahroudin@gmail.com Tabriz University of medical Sciences scientific Dr.Simin Taghavi
Golgasht Street; Tabriz University of medical sciences
Tabriz Iran (Islamic Republic of) +98 41 3553 9161 lahroudin@gmail.com Tabriz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: pregnant women with gestational age between 26 to 32 weeks with premature rupture of membranes (PROM); signing informed consent. Exclusion criteria: fetal abnormalities; genetic abnormalities that can affect fetal growth that have been checked by ultrasound at 18 to 20 weeks and 28 to 32 weeks. Along with trisomy screening marker with double or quad marker; precambrian patients; chronic high blood pressure; overt diabetes; pregnancy-related diabetes; detachment; prolapsed umbilical cord; chorioamnionitis; gestational age over 32 weeks (because there isn’t sufficient time to study the effects of progesterone); patient who have had a rupture of the membranes after 36 hours; patient who are in active phase. 15 years 48 years Female O42 Premature rupture of membranes, labour delayed by therapy Treatment - Drugs Treatment - Drugs Intervention group : progesterone ( 400 mg a daily intravaginal Control group: routine treatment includes injections of betamethasone 12 mg of progesterone administered every 12 hours Lengthening the interval between the pre-term delivery runny. Timepoint: Daily. Method of measurement: Physical examination. Improving Perinatal Outcomes. Timepoint: Follow baby daily until discharge. Method of measurement: Physical examination. Vice Chancellor for Research and Technology University of Medical Sciences Approved 2016-02-04 Ethics Committee of Tabriz University of Medical Sciences Ethics Committee Of Tabriz University Of Medical Sciences; Third Floor, Central Building of Number2, Golgasht Street Tabriz Iran (Islamic Republic of)