IRCT20220322054338N3 IRCT 2025-03-29 Vice President for Research, University of Sistan and Baluchestan The effect of vitamin D and calcium supplementation and squat exercises on angiogenesis indices in the elderly The effect of a course of vitamin D and calcium supplementation along with squat exercises on angiogenesis indices in the elderly 2025-04-04 anticipated 45 Complete https://irct.ir/trial/82109 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Randomization of numbers is done using Random Allocation software and permutation block method. People will be assigned to three groups using ternary permutation blocks. To do this, the letters A, B, and C will be considered for the two intervention and control groups, respectively. The possible states in the ternary block are six states including CAB, BCA, CBA, ACB, BAC, ABC. Each state will be written on a card. The cards will be assigned numbers one to six. Then, one of the six possible states will be selected using dice and based on that, the selected patients will be assigned to three groups. This process will continue until the sample size is completed, Blinding description: Participants in the supplement group will receive 1,000 mg of calcium daily and 50,000 IU of vitamin D weekly. The placebo groups will receive the same number of starch tablets and capsules. Before the study begins, the supplement and placebo packages will be marked by someone other than the researcher so that the researcher and participants are unaware of the type of capsules they are receiving. The supplement and placebo will be administered under the supervision of the same person. 3 Elderly. Intervention 1: Intervention group: 4 weeks of training with supplements, one 1000 mg calcium tablet per day along with one 50000 international units of vitamin D capsule per week and squat exercises 3 sessions a week. Intervention 2: Intervention group: 4 weeks of placebo training, one 1000 mg placebo tablet (containing lactose and edible paraffin) per day, along with one 50,000 IU placebo capsule (corn starch and Avicel) per week, and resistance squat training 3 sessions per week. Intervention 3: Control group: Tracking activities and daily regimen without any interference. Yes - There is a plan to make this available What will be shared: Participants' information will be made available to other researchers after being de-identified When: After the publication of the final research report. To whom: Researchers Conditions: Citing the findings by citing the source Where to obtain: Those interested in more information can contact through the email and address below: Mailing address: University of Zabol Email: elhamghasemi@uoz.ac.ir How to obtain: Those interested in more information can contact through the email and address below: Mailing address: University of Zabol Email: elhamghasemi@uoz.ac.ir Comments: