<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE trials [
<!ELEMENT trials (trial+)>

<!ELEMENT trial (main,contacts,countries,criteria,health_condition_code,health_condition_keyword,intervention_code,
          intervention_keyword,primary_outcome,secondary_outcome,secondary_sponsor,secondary_ids,source_support,ethics_reviews)>

<!ELEMENT main (trial_id,utrn?,reg_name,date_registration,primary_sponsor,public_title,acronym?,scientific_title,scientific_acronym?,
          date_enrolment,type_enrolment,target_size,recruitment_status,url?,study_type,study_design,phase,hc_freetext?,i_freetext?,results_actual_enrolment,results_date_completed,results_url_link,results_summary,           results_date_posted,results_date_first_publication,results_baseline_char,results_participant_flow,results_adverse_events,results_outcome_measures,results_url_protocol,results_IPD_plan, results_IPD_description)>
<!ELEMENT trial_id (#PCDATA)>
<!ELEMENT utrn (#PCDATA)>
<!ELEMENT reg_name (#PCDATA)>
<!ELEMENT date_registration (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT primary_sponsor (#PCDATA)>
<!ELEMENT public_title (#PCDATA)>
<!ELEMENT acronym (#PCDATA)>
<!ELEMENT scientific_title (#PCDATA)>
<!ELEMENT scientific_acronym (#PCDATA)>
<!ELEMENT date_enrolment (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT type_enrolment (#PCDATA)>
<!ELEMENT target_size (#PCDATA)>
<!ELEMENT recruitment_status (#PCDATA)><!-- Pending,Recruiting,Suspended,Complete,Other -->
<!ELEMENT url (#PCDATA)>
<!ELEMENT study_type (#PCDATA)><!-- interventional,observational -->
<!ELEMENT study_design (#PCDATA)>
<!ELEMENT phase (#PCDATA)>
<!ELEMENT hc_freetext (#PCDATA)>
<!ELEMENT i_freetext (#PCDATA)>
<!ELEMENT results_actual_enrolment (#PCDATA)>
<!ELEMENT results_date_completed (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_url_link (#PCDATA)>
<!ELEMENT results_summary (#PCDATA)>
<!ELEMENT results_date_posted (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_date_first_publication (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_baseline_char (#PCDATA)>
<!ELEMENT results_participant_flow (#PCDATA)>
<!ELEMENT results_adverse_events (#PCDATA)>
<!ELEMENT results_outcome_measures (#PCDATA)>
<!ELEMENT results_url_protocol (#PCDATA)>
<!ELEMENT results_IPD_plan (#PCDATA)>
<!ELEMENT results_IPD_description (#PCDATA)>


<!ELEMENT contacts (contact+)>
<!ELEMENT contact (type,firstname,middlename,lastname,address,city,country1,zip,telephone,email,affiliation)>
<!ELEMENT type (#PCDATA)><!-- Public,Scientific -->
<!ELEMENT firstname (#PCDATA)>
<!ELEMENT middlename (#PCDATA)>
<!ELEMENT lastname (#PCDATA)>
<!ELEMENT address (#PCDATA)>
<!ELEMENT city (#PCDATA)>
<!ELEMENT country1 (#PCDATA)>
<!ELEMENT zip (#PCDATA)>
<!ELEMENT telephone (#PCDATA)>
<!ELEMENT email (#PCDATA)>
<!ELEMENT affiliation (#PCDATA)>

<!ELEMENT countries (country2+)>
<!ELEMENT country2 (#PCDATA)>

<!ELEMENT criteria (inclusion_criteria,agemin,agemax,gender,exclusion_criteria)>
<!ELEMENT inclusion_criteria (#PCDATA)>
<!ELEMENT agemin (#PCDATA)>
<!ELEMENT agemax (#PCDATA)>
<!ELEMENT gender (#PCDATA)>
<!ELEMENT exclusion_criteria (#PCDATA)>

<!ELEMENT health_condition_code (hc_code+)>
<!ELEMENT hc_code (#PCDATA)>

<!ELEMENT health_condition_keyword (hc_keyword+)>
<!ELEMENT hc_keyword (#PCDATA)>

<!ELEMENT intervention_code (i_code+)>
<!ELEMENT i_code (#PCDATA)>

<!ELEMENT intervention_keyword (i_keyword+)>
<!ELEMENT i_keyword (#PCDATA)>

<!ELEMENT primary_outcome (prim_outcome+)>
<!ELEMENT prim_outcome (#PCDATA)>

<!ELEMENT secondary_outcome (sec_outcome+)>
<!ELEMENT sec_outcome (#PCDATA)>

<!ELEMENT secondary_sponsor (sponsor_name+)>
<!ELEMENT sponsor_name (#PCDATA)>

<!ELEMENT secondary_ids (secondary_id+)>
<!ELEMENT secondary_id (sec_id,issuing_authority)>
<!ELEMENT sec_id (#PCDATA)>
<!ELEMENT issuing_authority (#PCDATA)>

<!ELEMENT source_support (source_name+)>
<!ELEMENT source_name (#PCDATA)>

<!ELEMENT ethics_reviews (ethics_review+)>
<!ELEMENT ethics_review (status,approval_date,contact_name,contact_address,contact_phone,contact_email)>
<!ELEMENT status (#PCDATA)><!-- Not approved,Approved,NA -->
<!ELEMENT approval_date (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT contact_name (#PCDATA)>
<!ELEMENT contact_address (#PCDATA)>
<!ELEMENT contact_phone (#PCDATA)>
<!ELEMENT contact_email (#PCDATA)>
]>
<trials>
  <trial>
    <main>
      <trial_id>IRCT20210602051477N3</trial_id>
      <utrn></utrn>
      <reg_name>IRCT</reg_name>
      <date_registration>2025-03-15</date_registration>
      <primary_sponsor>Kharazmi University</primary_sponsor>
      <public_title>Comparing the effects of differential learning and nonlinear pedagogy in anterior cruciate ligament injury</public_title>
      <acronym>ACL</acronym>
      <scientific_title>Comparison of Plyometric Training by Differential Learning or Nonlinear Pedagogy Approach on Functional and Biomechanical Factors in Athletes at High Risk of ACL Injury: A Field Trial Study</scientific_title>
      <scientific_acronym></scientific_acronym>
      <date_enrolment>2025-09-23</date_enrolment>
      <type_enrolment>anticipated</type_enrolment>
      <target_size>48</target_size>
      <recruitment_status>Complete</recruitment_status>
      <url>https://irct.ir/trial/82157</url>
      <study_type>interventional</study_type>
      <study_design>Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: To randomize, the online randomization method (http://randomizer.org/Social Psychology Network Middletown, CT, USA, accessed on June 22, 2013) will be used, which is provided to researchers for free. In this way, participants are randomly assigned in a 1:1:1 allocation ratio to one of the groups: 1=non-linear pedagogy, 2=differential learning, and 3=control. To allocate concealment, the table of block random numbers will be used. For this purpose, random numbers will be placed in sealed and opaque envelopes inside the box. The other researcher, who is not aware of the initial assignment of the subjects, opens the envelopes and will continue the exercises after determining the assignment of the groups, Blinding description: In the present study, a single-blinded method will be used for blinding, in which only the outcome assessors are blinded. For this purpose, outcome assessors who are unaware of the participant allocation, research method, and hypotheses collect data related to the outcome variables.</study_design>
      <phase>N/A</phase>
      <hc_freetext>Prevention of anterior cruciate ligament injury.</hc_freetext>
      <i_freetext>Intervention 1: The first intervention group: Plyometric training combined with nonlinear learning pedagogy will be conducted for 8 weeks, 3 sessions per week, each session lasting 60 minutes, for a total of 24 training sessions. Intervention 2: Second intervention group: Plyometric exercises combined with differential learning pedagogy for 8 weeks, 3 sessions per week, each session lasting 60 minutes, for a total of 24 training sessions. Intervention 3: Control group: Participants will continue with their daily lives and will not receive any intervention.</i_freetext>
      <results_actual_enrolment></results_actual_enrolment>
      <results_date_completed></results_date_completed>
      <results_url_link></results_url_link>
      <results_summary></results_summary>
      <results_date_posted></results_date_posted>
      <results_date_first_publication></results_date_first_publication>
      <results_baseline_char></results_baseline_char>
      <results_participant_flow></results_participant_flow>
      <results_adverse_events></results_adverse_events>
      <results_outcome_measures></results_outcome_measures>
      <results_url_protocol></results_url_protocol>
      <results_IPD_plan>Yes - There is a plan to make this available</results_IPD_plan>
      <results_IPD_description>What will be shared:
The participant data form, study protocol, informed consent form, and study report will be published anonymously after the research is completed as an attachment to the article, as well as the results as an average of all participants.

When:
The access period to protocols and results will begin approximately 6 months after the results are published.

To whom:
Researchers working in scientific centers and universities, strength and conditioning coach, physiotherapists, and sports medicine specialists can access the results.

Conditions:
The research results will be published in the form of articles in scientific databases and will be accessible through this means.

Where to obtain:
To receive the study results, they can email the corresponding author.
Email address: majidhamoongard@gmail.com

How to obtain:
After contact, the corresponding author for the article will be responded to as soon as possible.

Comments:
</results_IPD_description>
    </main>
    <contacts>
      <contact>
        <type>public</type>
        <firstname>Majid Hamoongard</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>No. 43, Shahid Moftah Ave., Enghelab Blvd., Tehran Town</address>
        <city>Tehran</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip>15719-14911</zip>
        <telephone>+98 26 3457 9600</telephone>
        <email>std-majid.hamoongard@khu.ac.ir</email>
        <affiliation>The University of Kharazmi</affiliation>
      </contact>
      <contact>
        <type>scientific</type>
        <firstname>Majid Hamoongard</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>No. 43, Shahid Moftah Ave., Enghelab Blvd., Tehran Town</address>
        <city>Tehran</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip>15719-14911</zip>
        <telephone>+98 26 3457 9600</telephone>
        <email>std-majid.hamoongard@khu.ac.ir</email>
        <affiliation>The University of Kharazmi</affiliation>
      </contact>
    </contacts>
    <countries>
      <country2>Iran (Islamic Republic of)</country2>
    </countries>
    <criteria>
      <inclusion_criteria>All male university athletes at a competitive level (futsal, basketball and handball)
Normal body mass index in the range of 18.5 to 25
Having a score equal to or greater than 6 in the tuck jump test
Absence of any visible abnormalities in the trunk (hyper-kyphosis, hyper-lordosis, and severe scoliosis) and lower limbs (genu varum, genu valgum, and severe flat feet) and no acute and chronic musculoskeletal injury during the past year (any injury that causes the athlete to be away for a long time)
There is no history of injury or rupture of the anterior cruciate ligament and no medical history of neurocognitive, metabolic, hearing, and vision defects.
Absence of concussion or concussion-related symptoms (frequent headaches or migraines, eye movement deficits, and balance disorders) within the past five years</inclusion_criteria>
      <agemin>18 years</agemin>
      <agemax>26 years</agemax>
      <gender>Male</gender>
      <exclusion_criteria>Participation in injury risk reduction programs during the past year
Non-participation of subjects in two consecutive training sessions and three non-consecutive training sessions</exclusion_criteria>
    </criteria>
    <health_condition_code>
      <hc_code></hc_code>
    </health_condition_code>
    <health_condition_keyword>
      <hc_keyword></hc_keyword>
    </health_condition_keyword>
    <intervention_code>
      <i_code>Prevention</i_code>
      <i_code>Prevention</i_code>
      <i_code>N/A</i_code>
    </intervention_code>
    <intervention_keyword>
      <i_keyword>The first intervention group: Plyometric training combined with nonlinear learning pedagogy will be conducted for 8 weeks, 3 sessions per week, each session lasting 60 minutes, for a total of 24 training sessions.</i_keyword>
      <i_keyword>Second intervention group: Plyometric exercises combined with differential learning pedagogy for 8 weeks, 3 sessions per week, each session lasting 60 minutes, for a total of 24 training sessions.</i_keyword>
      <i_keyword>Control group: Participants will continue with their daily lives and will not receive any intervention.</i_keyword>
    </intervention_keyword>
    <primary_outcome>
      <prim_outcome>Knee and hip kinematics. Timepoint: Knee and hip kinematics will be measured at pre-test (before the start of the intervention) and post-test (after 8 weeks). Method of measurement: A motion capture system with 8 high-speed cameras (Kestrel 8.0 motion analysis, US) with a sampling frequency of 120 Hz will be used to measure 3D kinematics.</prim_outcome>
      <prim_outcome>Knee and hip Kinetics. Timepoint: Knee and hip kinetics will be measured at pre-test (before the start of the intervention) and post-test (after 8 weeks). Method of measurement: A Bertec force plate device, made in the United States, with dimensions of 60 x 40 cm (Bertec Corporation, Columbus, OH) with a sampling frequency of 1200 Hz will be used to collect kinetic data.</prim_outcome>
    </primary_outcome>
    <secondary_outcome>
      <sec_outcome>Triple crossover hop for distance test. Timepoint: It will be measured in the pre-test (before the intervention) and post-test (after 8 weeks). Method of measurement: The jump distance (meters) from the starting line to the foot heel will be considered the participant's record.</sec_outcome>
      <sec_outcome>Tuck jump test. Timepoint: It will be measured in the pre-test (before the intervention) and post-test (after 8 weeks). Method of measurement: 10-question scoring form for the tuck jump test.</sec_outcome>
      <sec_outcome>90 medial rotation hop for distance. Timepoint: It will be measured in the pre-test (before the intervention) and post-test (after 8 weeks). Method of measurement: The jump distance will be measured from the medial of the foot when jumping to the toes when landing.</sec_outcome>
      <sec_outcome>Medial side triple hop for distance test. Timepoint: It will be measured in the pre-test (before the intervention) and post-test (after 8 weeks). Method of measurement: The total jump distance after three consecutive steps is measured from the medial side of the foot when jumping to the medial side of the foot when landing.</sec_outcome>
      <sec_outcome>Coordination variability of lower extremity. Timepoint: It will be measured in the pre-test (before the intervention) and post-test (after 8 weeks). Method of measurement: A motion capture system (Kestrel 8.0 motion analysis, US) 8 cameras with a sampling frequency of 120 Hz.</sec_outcome>
    </secondary_outcome>
    <secondary_sponsor>
      <sponsor_name></sponsor_name>
    </secondary_sponsor>
    <secondary_ids>
      <secondary_id>
        <sec_id></sec_id>
        <issuing_authority></issuing_authority>
      </secondary_id>
    </secondary_ids>
    <source_support>
      <source_name>Kharazmi University</source_name>
    </source_support>
    <ethics_reviews>
      <ethics_review>
        <status>Approved</status>
        <approval_date>2025-02-23</approval_date>
        <contact_name>Research Ethics Committees of Kharazmi University</contact_name>
        <contact_address>No. 43, Shahid Moftah Ave., Enghelab Blvd., Tehran Town Tehran Tehran Iran (Islamic Republic of)</contact_address>
        <contact_phone></contact_phone>
        <contact_email></contact_email>
      </ethics_review>
    </ethics_reviews>
  </trial>
</trials>
