IRCT20130418013058N18 IRCT 2025-05-22 Mashhad University of Medical Sciences Crocin and Curcumin Effect on Multiple Sclerosis Evaluation of the Efficacy of Crocin and Curcumin Combinational Capsule on the severity of fatigue, pain and quality of life in patients with multiple sclerosis 2025-04-29 anticipated 40 Complete https://irct.ir/trial/82169 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Each capsule container will be assigned a four-digit code using a random number table. These codes will be randomly labeled onto each container by the pharmacist. The therapist will randomly provide the containers to patients without knowledge of the medication type. Consequently, the nature of each code will remain unknown until the results are analyzed, Blinding description: Crocin-curcumin capsules and placebo capsules will be prepared with similar shape, color, and size, stored in dark containers, and coded by a pharmacist. The treating physician, researcher, and patient will be blinded to the codes on the aforementioned containers. 2-3 MS or Multiple sclerosis. Intervention 1: Intervention group: During the two-month period, they will receive oral capsules containing a combination of 7.5 mg crocin and 150 mg curcumin twice daily (BID), totaling 15 mg crocin and 300 mg curcumin per day. Intervention 2: Control group: Receiving placebo, with placebo capsules administered twice daily (BID) throughout the two-month period. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is After the project, the information will be published in the form of an article.