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IRCT20241211064021N4 IRCT 2025-03-21 Hamedan University of Medical Sciences Comparison of the effects of propolis and chlorhexidine mouthwash on oral health and impacted mandibular wisdom teeth Studying the effect of herbal mouthwash (propolis) on the reduction of gingival index, plaque index, and prevalence of dry socket in impacted mandibular wisdom teeth compared to chlorhexidine 2025-04-12 anticipated 60 Complete https://irct.ir/trial/82446 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, a simple randomization method will be used to implement random assignment. In this way, 60 consecutive numbers (from 1 to 60) will be written separately on paper and placed in a container. Then, each participant in the experiment will be asked to randomly select one of these 60 numbers from the container containing the numbers.People who chose numbers 1 to 30 will be assigned to Group A, and people who chose numbers 31 to 60 will be assigned to Group B, Blinding description: Propolis mouthwash and chlorhexidine mouthwash are produced with similar appearance, color, and odor. If possible, additives are used to make both mouthwashes look exactly the same. This is done to prevent the mouthwash from being identified based on appearance. Both mouthwashes are packaged in identical, indistinguishable bottles.In this type of blinding, neither the participants know which mouthwash they are receiving nor do the researchers who perform the clinical assessments (such as measuring gingival and plaque indices). The primary investigator codes the bottles (using numbers). This list is not made available to the researchers or participants until the end of the study.Participants are given coded bottles and told to use the mouthwash according to specific instructions (for example, twice a day after brushing their teeth). 3 Studying the effect of herbal mouthwash (propolis) on the reduction of gingival index, plaque index, and prevalence of dry socket in impacted mandibular wisdom teeth compared to chlorhexidine. Intervention 1: Intervention group: The effect of herbal mouthwash (propolis) is to rinse your mouth with 10 ml of mouthwash for 30 seconds, one hour after brushing your teeth, twice a day (morning and night), as recommended by the manufacturer, and avoid eating and drinking, and preferably rinsing your mouth. This should be done starting the night of surgery and continuing for two weeks. Intervention 2: Control group: Simultaneously uses chlorhexidine mouthwash. This group serves as a benchmark for comparison with the effect of propolis. Yes - There is a plan to make this available What will be shared: Much of the data is potentially shareable When: Access to the data will be available immediately after the publication of the final article To whom: All researchers, researchers and clinical experts will be allowed to access the data of this study. Conditions: It will be welcomed to conduct extensive analysis on the data of this study along with the data of other studies to write meta-analysis review articles. Where to obtain: For more information, please send an email to Dr. Pouria Karimi. All correspondence will be sent to the email address: atmonero@gmail.com How to obtain: After making a phone call and submitting a request via email, the final answer will be sent within at least 1 month. Comments:
public Pouria Karimi
Shahid Fahmedeh st
Hamadan Iran (Islamic Republic of) 6517838678 +98 81 3131 0000 atmonero@gmail.com Hamedan University of Medical Sciences scientific Amir Najafi
Shahid Fahmedeh st
Hamadan Iran (Islamic Republic of) 6517838678 +98 81 3131 0000 dr_amn69@yahoo.com Hamedan University of Medical Sciences Iran (Islamic Republic of) Having impacted wisdom teeth in the lower jaw Not using other mouthwashes Plaque index and gum index 15 years 30 years Both Pregnant people People with cardiovascular problems People who use antibiotic medications for any reason K05.1 Chronic gingivitis Treatment - Drugs Treatment - Drugs Intervention group: The effect of herbal mouthwash (propolis) is to rinse your mouth with 10 ml of mouthwash for 30 seconds, one hour after brushing your teeth, twice a day (morning and night), as recommended by the manufacturer, and avoid eating and drinking, and preferably rinsing your mouth. This should be done starting the night of surgery and continuing for two weeks. Control group: Simultaneously uses chlorhexidine mouthwash. This group serves as a benchmark for comparison with the effect of propolis. The amount of gum index reduction. Timepoint: Before intervention: Assessment of the initial condition before starting to use the mouthwash. After intervention: Assessment at specific times after the start of treatment, measured on days 7 and 14. Method of measurement: They are measured using standard clinical methods, which include examination of the teeth and gums by a trained dentist and researcher. Instruments such as a probe are used to measure the depth of the gingival pocket or visual observation is used to determine the presence of plaque. Prevalence of dry cavity. Timepoint: Before intervention: Assessment of the initial condition before starting to use the mouthwash. After intervention: Assessment at specific times after the start of treatment, measured on days 7 and 14. Method of measurement: It is usually assessed through clinical records and reports of complications from patients after wisdom tooth extraction. Patients' perception of pain or discomfort. Timepoint: Before the intervention: To assess the initial condition of the patients. During the intervention: Periodic assessment (every week and every month) to observe changes. Method of measurement: It is measured through rating scales (such as a 0 to 10 rating scale) in which patients report their level of pain. Hamedan University of Medical Sciences Approved 2024-11-23 Research Ethics Committee of Hamadan University of Medical Sciences Shahid Fahmideh St Hamadan Hamadan Iran (Islamic Republic of)