IRCT201110187839N1 IRCT 2011-11-13 Isfahan University of Medical Sciences Effect of Sertraline on Schizophrenia Efficacy of Serteralin add-on therapy to Atypical Antipsychotics on maintenance therapy of schizophrenia patients on depression and level of function: Isfahan 2011-12 2011-05-22 anticipated 54 Complete https://irct.ir/trial/8283 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Single, Purpose: Treatment. N/A schizophrenia. Sertraline 50 mg/day was started for intervention group that could rise to 200mg/day gradually.In control group placbo pills that are identical to sertraline was prescribed.Both drug and placebo daily dosage was 1 tablet per day..

public Ghadir Mohammad Hoseiny

Noor hospital, Ostandari st., Isfahan, Iran.

isfahan Iran (Islamic Republic of) +98 31 1447 8669 ghadir-mhb@resident.mui.ac.ir drghadir@gmail.com Isfahan University of Medical Sciences scientific Victoria Omranifard

Noor hospital, Ostandari st., Isfahan, Iran

Isfahan Iran (Islamic Republic of) +98 31 1222 2727 v_omranifard@med.mui.ac.ir Isfahan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria:1-age:16-65y/o; 2-no substance abuse or sever medical disease; 3-no pregnancy or breast feeding; 4- patients medication should be one of atypical antipsychotics(Risperidone,Olanzapine,Aripiperazole,Quetiapine or Clozapine); 5- the patients are not in acute phase of disease; 6- the patients are on maintenance medication. Exclusion criteria:1-sever side effects; 2-no intrest in patient or his/her family to maintain on the study; 3-pregnancy; 4-drug non-tolerance. 16 years 65 years Both F20 The schizophrenic disorders are characterized in general by fundamental and characteristic distortions of thinking and perception, and affects that are inappropriate or blunted. Clear consciousness and intellectual capacity are usually maintained although Treatment - Drugs Sertraline 50 mg/day was started for intervention group that could rise to 200mg/day gradually.In control group placbo pills that are identical to sertraline was prescribed.Both drug and placebo daily dosage was 1 tablet per day. Score of Depression. Timepoint: before starting study and after weeks 8,12. Method of measurement: CDSS(Calgray Depressive Scale of Schizophrenia). Score of Quality of Life. Timepoint: before starting study and after weeks 8,12. Method of measurement: QLS questionare (Quality of life in Schizophrenia). Score of Psychosis. Timepoint: before starting study and after weeks 8,12. Method of measurement: PANSS questionare (Positive And Negative Syndrome Scale). Level of Function. Timepoint: before starting study and after weeks 8,12. Method of measurement: GAF questionare (Global Assessment of Function). Side-effects of medication. Timepoint: weeks 8,12. Method of measurement: quastionare of side effects. Isfahan University of Medical Sciences Approved 2011-05-20 Isfahan University of Medical Sciences Isfahan University of Medical Sciences, Azadi sq., Isfahan, Iran. isfahan Iran (Islamic Republic of)