IRCT20250421065412N1 IRCT 2025-05-29 Iran University of Medical Sciences The Effect of Xylapy cream 5% on Postoperative Sore Throat in Adults Investigating the Effect of Xylapy cream 5% on Postoperative Sore Throat in Adults Following General Anesthesia with a Laryngeal Mask Airway: A Double-Blind Clinical Trial Study" 2025-05-05 anticipated 300 Complete https://irct.ir/trial/83042 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: In this study, the block random allocation method will be employed. First, the randomization sequence will be generated before the study commences and patient recruitment, ensuring that the initial blocks containing 4 parts are created by considering all possible allocation scenarios for the intervention group (I) and control group (C) within each block (such as I-I-C-C, I-C-I-C, etc.). Then, the created blocks will be randomly numbered using the Excel RAND function. After sorting the numbers from smallest to largest, the order of block selection will be determined, and we will proceed to select the blocks. Block selection will continue until the required sample size is reached. To conceal the allocation, the treatments will be coded and placed in sealed envelopes. These envelopes will be opened only after the patient is registered in the study. In each block, 4 allocations (2 cases in the intervention group and 2 cases in the control group) will occur, and this process will continue until the target sample size is met, Blinding description: Since the treatment methods used are unnamed and will be identified by specific codes, the outcome assessor and analyst will remain blinded to the type of intervention. 2-3 Anesthesia methods in surgeries. Intervention 1: Intervention group: In this group, Zylapril 5% cream (a topical anesthetic combining 2.5% lidocaine + 2.5% prilocaine, manufactured by Tehran Chemi Pharmaceutical Company) will be applied once to the cuff of their laryngeal airway mask. The anesthesia protocol included midazolam (0.03–0.05 mg/kg), fentanyl (3 mcg/kg), lidocaine (1 mg/kg), and propofol (2–3 mg/kg), with anesthesia maintained using isoflurane (MAC 1.5). The size of the airway mask was selected based on the patient’s weight, and the material and manufacturer of the mask were standardized for all patients. Intervention 2: Control Group: No local anesthetic agent will be applied to the cuff of their laryngeal airway mask (LMA). The anesthesia protocol included midazolam (0.03–0.05 mg/kg), fentanyl (3 mcg/kg), lidocaine (1 mg/kg), and propofol (2–3 mg/kg), with anesthesia maintained using isoflurane (MAC 1.5). The size of the airway mask was determined based on the patient’s weight, and the material and manufacturer of the mask will be standardized for all patients. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Data will be collected for research purposes, and the analyzed results will be published in reports and articles. However, raw data may also be disclosed if deemed appropriate.